Early pregnancy loss affects ∼15% of all implantation-confirmed human conceptions.
However, evolutionarily conserved molecular mechanisms that regulate self-renewal of …

GATA transcription factors are implicated in establishing cell fate during mammalian development.
In early mammalian embryos, GATA3 is selectively expressed in the extraembryonic …

Cell fate decisions are fundamental to the development of multicellular organisms. In mammals
the first cell fate decision involves segregation of the pluripotent inner cell mass and the …

Drug resistance is a problem that hinders the numerous successes of chemotherapeutic
intervention of cancer and continues to be a major obstacle for cures. Till date, several attempts …

Early mammalian development is crucially dependent on the establishment of oxidative
energy metabolism within the trophectoderm (TE) lineage. Unlike the inner cell mass, TE cells …

Background At the early stages of carcinogenesis, the induction of tumor specific T cell
mediated immunity seems to block the tumor growth and give protective anti-tumor immune …

Umbilical cord blood (UCB) engraftment is in part limited by graft cell dose, generally one
log less than that of bone marrow (BM)/peripheral blood (PB) cell grafts. Strategies toward …

TAMs, present in the tumor microenvironment, play an immunosuppressive role, leading to
tumor progression and metastasis. Recently, numerous attempts have been made to switch …

Embryonic stem cell (ESC) pluripotency is orchestrated by distinct signaling pathways that
are often targeted to maintain ESC self-renewal or their differentiation to other lineages. We …

Multidrug resistance (MDR) mediated by the over expression of drug efflux protein P-glycoprotein
(P-gp) is one of the major impediments to successful treatment of cancer. P-gp acts as …