CpG island hypermethylation and global genomic hypomethylation are common epigenetic
features of cancer cells. Less attention has been focused on histone modifications in cancer …

The acetylation of histones increases the accessibility of nucleosomal DNA to transcription
factors [1,2], relieving transcriptional repression [3] and correlating with the potential for …

Histone methylation plays a key role in establishing and maintaining stable gene expression
patterns during cellular differentiation and embryonic development. Here, we report the …

Enhancer of Zeste is a Polycomb Group protein essential for the establishment and maintenance
of repression of homeotic and other genes. In the early embryo it is found in a complex …

Histone posttranslational modifications (PTMs) and sequence variants regulate genome
function. Although accumulating evidence links particular PTM patterns with specific genomic …

Epigenetic states defined by chromatin can be maintained through mitotic cell division.
However, it remains unknown how histone-based information is transmitted. Here we combine …

Ischemic cardiomyopathy is one of the main causes of death, which may be prevented by
stem cell-based therapies. SDF-1α is the major chemokine attracting stem cells to the heart. …

Most multi-cellular organisms adopt a specific gene expression pattern during cellular
differentiation. Once established, this pattern is frequently maintained over several cell divisions …

Cell surface proteolysis is essential for communication between cells and results in the
shedding of membrane‐protein ectodomains. However, physiological substrates of the …

Reversible histone acetylation plays an important role in regulation of chromatin structure
and function. Here, we report that the human orthologue of Drosophila melanogaster MOF, …