User profiles for Axel Martinelli

Axel Martinelli

Institute for Research in Biomedicine, Bellinzona
Verified email at irb.usi.ch
Cited by 2112

[HTML][HTML] The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

R Laing, T Kikuchi, A Martinelli, IJ Tsai, RN Beech… - Genome biology, 2013 - Springer
Background The small ruminant parasite Haemonchus contortus is the most widely used
parasitic nematode in drug discovery, vaccine development and anthelmintic resistance …

[HTML][HTML] Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm

…, K Brooks, U Chaudhry, K Maitland, A Martinelli… - Communications …, 2020 - nature.com
Haemonchus contortus is a globally distributed and economically important gastrointestinal
pathogen of small ruminants and has become a key nematode model for studying …

[HTML][HTML] Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus …

…, R Laing, DJ Bartley, E Redman, A Martinelli… - BMC genomics, 2019 - Springer
Background Infections with helminths cause an enormous disease burden in billions of
animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of …

[HTML][HTML] Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria …

P Hunt, A Martinelli, K Modrzynska, S Borges… - BMC genomics, 2010 - Springer
Background Classical and quantitative linkage analyses of genetic crosses have traditionally
been used to map genes of interest, such as those conferring chloroquine or quinine …

[HTML][HTML] Artemisinin resistance in rodent malaria-mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

G Henriques, A Martinelli, L Rodrigues, K Modrzynska… - Malaria journal, 2013 - Springer
Background The control of malaria, caused by Plasmodium falciparum, is hampered by the
relentless evolution of drug resistance. Because artemisinin derivatives are now used in the …

[HTML][HTML] The cytochrome P450 family in the parasitic nematode Haemonchus contortus

…, AA Morrison, A Rezansoff, A Martinelli… - International journal for …, 2015 - Elsevier
Haemonchus contortus, a highly pathogenic and economically important parasitic nematode
of sheep, is particularly adept at developing resistance to the anthelmintic drugs used in its …

Comparative genome analysis of two Cryptosporidium parvum isolates with different host range

G Widmer, Y Lee, P Hunt, A Martinelli, M Tolkoff… - Infection, Genetics and …, 2012 - Elsevier
Parasites of the genus Cryptosporidium infect the intestinal and gastric epithelium of different
vertebrate species. Some of the many Cryptosporidium species described to date differ …

A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites

A Martinelli, S Cheesman, P Hunt… - Proceedings of the …, 2005 - National Acad Sciences
Vaccine research in malaria has a high priority. However, identification of specific antigens
as candidates for vaccines against asexual blood stages of malaria parasites has been …

Linkage group selection: rapid gene discovery in malaria parasites

R Culleton, A Martinelli, P Hunt, R Carter - Genome research, 2005 - genome.cshlp.org
The identification of parasite genes controlling phenotypes such as drug resistance, virulence,
immunogenicity, and transmission is vital to malaria research. Classical genetic methods …

[HTML][HTML] A single test approach for accurate and sensitive detection and taxonomic characterization of trypanosomes by comprehensive analysis of internal transcribed …

AK Gaithuma, J Yamagishi, A Martinelli… - PLoS neglected …, 2019 - journals.plos.org
To improve our knowledge on the epidemiological status of African trypanosomiasis, better
tools are required to monitor Trypanosome genotypes circulating in both mammalian hosts …