A prominent feature of sensitizing environmental compounds that cause allergic contact
dermatitis is the rapid induction of an innate inflammatory response that seems to provide …

Clonal composition and T cell receptor (TCR) repertoire of CD4 + and CD8 + T cells
infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with …

Influx of macrophages plays a crucial role in tissue repair. However, the precise function of
macrophages during the healing response has remained a subject of debate due to their …

Recognition of DNA and RNA by endosomal and cytosolic sensors constitutes a central
element in the detection of microbial invaders by the innate immune system. However, the …

The regulatory T (Treg) cells restrain immune responses through suppressor-function
elaboration that is dependent upon expression of the transcription factor Foxp3. Despite a critical …

Neutrophil recruitment is an important early step in controlling tissue infections or injury.
Here, we report that this influx depends on both tissue-resident mast cells and macrophages. …

We surveyed the T cell receptor repertoire in three separate compartments (brain, cerebrospinal
fluid, and blood) of two multiple sclerosis patients who initially had diagnostic brain …

Interleukin (IL)-10 is a regulator of inflammatory responses and is secreted by a variety of
different cell types including T cells. T regulatory cells have been shown to suppress immune …

Although tremendous progress has been achieved in understanding the molecular basis of
tissue repair and regeneration in diverse model organisms, the tendency of mammals for …

IL-10 plays a central role in restraining the vigor of inflammatory responses, but the critical
cellular sources of this counter-regulatory cytokine remain speculative in many disease …