User profiles for Ayden Saffari
 | Ayden SaffariGenomics plc Verified email at genomicsplc.com Cited by 629 |
Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one …
Background Mounting evidence suggests that nutritional exposures during pregnancy
influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with …
influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with …
Estimation of a significance threshold for epigenome‐wide association studies
Epigenome‐wide association studies (EWAS) are designed to characterise population‐level
epigenetic differences across the genome and link them to disease. Most commonly, they …
epigenetic differences across the genome and link them to disease. Most commonly, they …
Integrated polygenic tool substantially enhances coronary artery disease prediction
Background: There is considerable interest in whether genetic data can be used to improve
standard cardiovascular disease risk calculators, as the latter are routinely used in clinical …
standard cardiovascular disease risk calculators, as the latter are routinely used in clinical …
[HTML][HTML] Epigenetic supersimilarity of monozygotic twin pairs
Background Monozygotic twins have long been studied to estimate heritability and explore
epigenetic influences on phenotypic variation. The phenotypic and epigenetic similarities of …
epigenetic influences on phenotypic variation. The phenotypic and epigenetic similarities of …
[HTML][HTML] Validation of an integrated risk tool, including polygenic risk score, for atherosclerotic cardiovascular disease in multiple ethnicities and ancestries
The American College of Cardiology / American Heart Association pooled cohort equations
tool (ASCVD-PCE) is currently recommended to assess 10-year risk for atherosclerotic …
tool (ASCVD-PCE) is currently recommended to assess 10-year risk for atherosclerotic …
Bigmelon: tools for analysing large DNA methylation datasets
Motivation The datasets generated by DNA methylation analyses are getting bigger. With
the release of the HumanMethylationEPIC micro-array and datasets containing thousands of …
the release of the HumanMethylationEPIC micro-array and datasets containing thousands of …
[HTML][HTML] Effect of maternal preconceptional and pregnancy micronutrient interventions on children's DNA methylation: Findings from the EMPHASIS study
Background Maternal nutrition in pregnancy has been linked to offspring health in early and
later life, with changes to DNA methylation (DNAm) proposed as a mediating mechanism. …
later life, with changes to DNA methylation (DNAm) proposed as a mediating mechanism. …
[HTML][HTML] RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation
Background A gap exists in our mechanistic understanding of how genetic and environmental
risk factors converge at the molecular level to result in the emergence of autism symptoms. …
risk factors converge at the molecular level to result in the emergence of autism symptoms. …
[HTML][HTML] Environmentally sensitive hotspots in the methylome of the early human embryo
In humans, DNA methylation marks inherited from gametes are largely erased following
fertilisation, prior to construction of the embryonic methylome. Exploiting a natural experiment of …
fertilisation, prior to construction of the embryonic methylome. Exploiting a natural experiment of …
[HTML][HTML] Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children's health in India and Sub-Saharan Africa
Background Animal studies have shown that nutritional exposures during pregnancy can
modify epigenetic marks regulating fetal development and susceptibility to later disease, …
modify epigenetic marks regulating fetal development and susceptibility to later disease, …