Single-cell RNA sequencing and high-dimensional cytometry can be used to generate detailed
trajectories of dynamic biological processes such as differentiation or development. Here …

Immune responses generally decline with age. However, the dynamics of this process at the
individual level have not been characterized, hindering quantification of an individual’s …

While many diseases of aging have been linked to the immunological system, immune metrics
capable of identifying the most at-risk individuals are lacking. From the blood immunome …

Single-cell technologies allow characterization of cancer samples as continuous
developmental trajectories. Yet, the obtained temporal resolution cannot be leveraged for a …

Skin sun exposure induces two protection programs: stress responses and pigmentation,
the former within minutes and the latter only hours afterward. Although serving the same …

Tofacitinib is a novel inhibitor of Janus kinase (JAK) 3 and JAK1 is recently introduced as
treatment for rheumatoid arthritis. 1 The JAK inhibitors are at the focus of research in a myriad …

(1) Background: Sepsis is a leading cause of death and a global public health problem.
Accordingly, deciphering the underlying molecular mechanisms of this disease and the …

Background: Previous studies have reported the fundamental role of immunoregulatory
proteins in the clinical phenotype and outcome of sepsis. This study investigated two functional …

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a surface protein on T cells, that has
an inhibitory effect on the host immune reaction and prevents overreaction of the immune …

Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is a coinhibitory checkpoint protein
expressed on the surface of T cells. A recent study by our working group revealed that the …