Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

Transcriptional regulation and posttranscriptional processing underlie many cellular and
organismal phenotypes. We used RNA sequence data generated by Genotype-Tissue …

The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while
the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We …

The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund,
was established to study the correlation between human genetic variation and tissue-specific …

The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding regions
of the genome. One possible hypothesis is that these GWAS risk loci alter the individual's …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Understanding gene function and regulation in homeostasis and disease requires knowledge
of the cellular and tissue contexts in which genes are expressed. Here, we applied four …