Massively parallel interrogation and mining of natively paired human TCRαβ repertoires
MJ Spindler, AL Nelson, EK Wagner… - Nature …, 2020 - nature.com
T cells engineered to express antigen-specific T cell receptors (TCRs) are potent therapies
for viral infections and cancer. However, efficient identification of clinical candidate TCRs is …
for viral infections and cancer. However, efficient identification of clinical candidate TCRs is …
Network-guided discovery of extensive epistasis between transcription factors involved in aliphatic glucosinolate biosynthesis
Plants use diverse mechanisms influenced by vast regulatory networks of indefinite scale to
adapt to their environment. These regulatory networks have an unknown potential for …
adapt to their environment. These regulatory networks have an unknown potential for …
Epistatic Transcription Factor Networks Differentially Modulate Arabidopsis Growth and Defense
How a plant regulates the relationship between plant growth and plant defense is critical for
understanding plant fitness or yield. Yet, little about the required complex underlying …
understanding plant fitness or yield. Yet, little about the required complex underlying …
[HTML][HTML] Preferential identification of agonistic OX40 antibodies by using cell lysate to pan natively paired, humanized mouse-derived yeast surface display libraries
To discover therapeutically relevant antibody candidates, many groups use mouse
immunization followed by hybridoma generation or B cell screening. One modern approach is to …
immunization followed by hybridoma generation or B cell screening. One modern approach is to …
High-throughput screening for rare antigen-reactive TCRs using natively-paired TCRαβ expression libraries generated from millions diverse primary T cells
MJ Spindler, AL Nelson, JM Heather… - The Journal of …, 2020 - journals.aai.org
A major goal of T cell research is to profile the repertoire of antigen-reactive TCRs targeting
specific peptide: MHCs (pMHC). Single cell sorting of pMHC-binding T cells using multimers …
specific peptide: MHCs (pMHC). Single cell sorting of pMHC-binding T cells using multimers …
[HTML][HTML] Quantitative measurement of pathogen specific human memory T cell repertoire diversity using a CDR3β-specific microarray
X Wang, S Jia, L Meyer, MB Yassai, YN Naumov… - BMC genomics, 2007 - Springer
Background Providing quantitative microarray data that is sensitive to very small differences
in target sequence would be a useful tool in any number of venues where a sample can …
in target sequence would be a useful tool in any number of venues where a sample can …
Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features
The potential pathogenetic mechanisms underlying the varied morphology of congenital
pulmonary airway malformations (CPAMs) have not been molecularly determined, but a subset …
pulmonary airway malformations (CPAMs) have not been molecularly determined, but a subset …
Composite Bodies: Race, Gender, and Dis/ability in Fairy Tale Performance
C Case - 2023 - d-scholarship.pitt.edu
This dissertation interrogates the ways in which racial, gendered, dis/abled, and technological
modes of embodiment reimagine what fairy tale performances can signify and who they …
modes of embodiment reimagine what fairy tale performances can signify and who they …
[PDF][PDF] UNE Expands Across Route 9
M SIMOES - core.ac.uk
… The team is also getting strong play from Junior Michaela Franey and solid goal tending
from Junior Ayla Nelson. "The new players are fitting in great," Franey said. "We would not be …
from Junior Ayla Nelson. "The new players are fitting in great," Franey said. "We would not be …
[PDF][PDF] The Foundation of Ayla: A Nabataean Port on the Red Sea
ST Parker - Studies in the History and Archaeology of Jordan, 2009 - publication.doa.gov.jo
… of Ayla is provided by Strabo (Geography 16.2.30, 16.4.4) who mentions a polis called Ayla
… Therefore, documentary sources suggest that Ayla was founded sometime between the late …
… Therefore, documentary sources suggest that Ayla was founded sometime between the late …