Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases
and controls, and we found that a previously described variant in the transcription factor 7-…

Given the importance of Africa to studies of human origins and disease susceptibility, detailed
characterization of African genetic diversity is needed. The African Genome Variation …

We recently described an association between risk of type 2diabetes and variants in the
transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (…

The evidence for the existence of genetic susceptibility variants for the common form of
hypertension (“essential hypertension”) remains weak and inconsistent. We sought genetic …

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However,
little is known about the genetic risk in African Americans despite the recent identification of …

ApolipoproteinL1 (APOL1) protects humans and some primates against several African
trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African …

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups;
yet, few have performed genome-wide association studies (GWASs) in AA. Among people …

Genomic studies in African populations provide unique opportunities to understand disease
etiology, human diversity, and population history. In the largest study of its kind, comprising …