Multiple studies have identified conserved genetic pathways and small molecules associated
with extension of lifespan in diverse organisms. However, extending lifespan does not …

Scaffold proteins serve important roles in cellular signaling by integrating inputs from
multiple signaling molecules to regulate downstream effectors that, in turn, carry out specific …

The nematode Caenorhabditis elegans constitutes a leading animal model to study how
signaling pathway components function in conserved biological processes. Here, we describe …

Aging is a significant risk factor for several diseases. Studies have uncovered multiple signaling
pathways that modulate aging, including insulin/insulin-like growth factor-1 signaling (IIS…

During aging, environmental stressors and mutations along with reduced DNA repair cause
germ cell aneuploidy and genome instability, which limits fertility and embryo development. …

The present study describes the beneficial effects of potential probiotic E. coli 16 (pUC8:16gfp)
expressing Vitreoscilla hemoglobin (vgb) gene, associated with bacterial respiration …

Background Caenorhabditis elegans seam cells serve as a good model to understand how
genes and signaling pathways interact to control asymmetric cell fates. The stage-specific …

Chromatin modification genes play crucial roles in development and disease. In Caenorhabditis
elegans, the class I histone deacetylase family member hda-1 , a component of the …

The Heat Shock Response (HSR) is a highly conserved genetic system charged with
protecting the proteome in a wide range of organisms and species. Experiments since the early …

The nematode Caenorhabditis elegans is a simple model host for studying the interaction
between bacterial pathogens and the metazoan innate immune system. In the last two decades…