INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Highlights • More than 40 loci of interest have been associated with the risk of developing
AD. • Recent genetic data clearly implicate microglia as involved in the pathophysiological …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

Alzheimer’s disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…

Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene
as the most important genetic susceptibility locus in Alzheimer’s disease (AD) after APOE. …

… progenitor cells toward the myeloid and B-lymphoid lineage by progressively partitioning
into CD14 + monocytes and macrophages, CD15 + neutrophils and CD19 + B cells 45 , the cell …

APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask
effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the …