Matrix metalloproteinases (MMPs), originally discovered to function in the breakdown of
extracellular matrix proteins, have gained the status of regulatory proteases in signaling events …

Foxp3 + regulatory T (T reg ) cells are a crucial immunosuppressive population of CD4 + T
cells, yet the homeostatic processes and survival programs that maintain the T reg cell pool …

Matrix metalloproteinases (MMPs) constitute a family of more than 20 endopeptidases.
Identification of specific matrix and non-matrix components as MMP substrates showed that, …

The action radius of matrix metalloproteinases or MMPs is not restricted to massive
extracellular matrix (ECM) degradation, it extends to the proteolysis of numerous secreted and …

Background Murine models are a crucial component of gut microbiome research.
Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-…

Background Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition
driven by excessive CD8 + T-cell activation. HLH occurs as both acquired and familial …

Gelatinase B/matrix metalloproteinase-9 (MMP-9) is a key enzyme involved in inflammatory,
hematological, vascular and neoplastic diseases. In previous studies, we explored the …

Matrix metalloproteinases (MMPs) are classically associated with the turnover of secreted
structural and functional proteins. Although MMPs have been shown to process also a …

Autoimmune diseases of the eye, exemplified by Beh cet disease and Vogt‐Koyanagi‐Harada
disease, are a major cause of blindness. We studied interphotoreceptor retinoid‐binding …

The use of genetically modified mice, ie transgenic as well as gene knockout (KO) and knock-in
mice, has become an established tool to study gene function in many animal models for …