Accumulation of depolarized mitochondria within β‐cells has been associated with oxidative
damage and development of diabetes. To determine the source and fate of depolarized …

NLRP3 is an important pattern recognition receptor involved in mediating inflammasome
activation in response to viral and bacterial infections as well as various proinflammatory stimuli …

Dysregulation of autophagy, a cellular catabolic mechanism essential for degradation of
misfolded proteins, has been implicated in multiple neurodegenerative diseases. However, the …

Caspases were originally identified as important mediators of inflammatory response and
apoptosis. Recent discoveries, however, have unveiled their roles in mediating and …

Inflammation is triggered by a repertoire of receptors detecting infections and damages.
Some of these receptors directly bind microbial ligands, while others recognize endogenous …

Autophagy has been recently proposed to be a component of the innate cellular immune
response against several types of intracellular microorganisms. However, other intracellular …

Autophagy is a cellular catabolic mechanism that plays an essential function in protecting
multicellular eukaryotes from neurodegeneration, cancer, and other diseases. However, we …

Caspase-4/5 in humans and caspase-11 in mice bind hexa-acylated lipid A, the lipid moeity
of lipopolysaccharide (LPS), to induce the activation of non-canonical inflammasome. …

NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling
the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits …

La réponse immunitaire innée protège l’organisme par la détection rapide des agents
pathogènes et des lésions via des récepteurs spécialisés, dont NLRP3. Celui-ci assemble un …