Endocrine-disrupting chemicals (EDCs) substantially cost society as a result of increases in
disease and disability but—unlike other toxicant classes such as carcinogens—have yet to …

This review covers recent findings on the main categories of thyroid hormone–disrupting
chemicals and their effects on brain development. We draw mostly on epidemiological and …

The vital roles of thyroid hormone in multiple aspects of perinatal brain development have
been known for over a century. In the last decades, the molecular mechanisms underlying …

Nonviral gene transfer into the central nervous system (CNS) offers the prospect of providing
safe therapies for neurological disorders and manipulating gene expression for studying …

Generally, cationic vector-based intravenous delivery of DNA is hindered by interactions of
positively charged complexes with serum proteins. However, if optimally formulated, cationic …

Currently in vivo gene delivery by synthetic vectors is hindered by the limited diffusibility of
complexes in extracellular fluids and matrices. Here we show that certain formulations of …

Glucocorticoid receptor (GR) activation induces apoptosis of granule cells in the hippocampus.
In contrast, neuroprotection is seen after mineralocor‐ticoid receptor (MR) activation. To …

Striated muscle is the only tissue found to be capable of taking up and expressing reporter
genes that are transferred in the form of plasmid DNA. Thus, direct gene transfer is a potential …

Thyroid hormones (TH) are essential for brain development. However, information on if and
how this key endocrine factor affects adult neurogenesis is fragmentary. We thus …

Background Efficient in vivo vectors are needed to exploit the enormous potential of RNA
interference (RNAi). Such methods require optimisation for specific delivery routes, tissues and …