[HTML][HTML] Thy1-GCaMP6 Transgenic Mice for Neuronal Population Imaging In Vivo
Genetically-encoded calcium indicators (GECIs) facilitate imaging activity of genetically
defined neuronal populations in vivo. The high intracellular GECI concentrations required for in …
defined neuronal populations in vivo. The high intracellular GECI concentrations required for in …
Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons
MS Cembrowski, L Wang, K Sugino, BC Shields… - elife, 2016 - elifesciences.org
10.7554/eLife.14997.001 Clarifying gene expression in narrowly defined neuronal populations
can provide insight into cellular identity, computation, and functionality. Here, we used …
can provide insight into cellular identity, computation, and functionality. Here, we used …
[PDF][PDF] Spatial gene-expression gradients underlie prominent heterogeneity of CA1 pyramidal neurons
…, JL Bachman, L Wang, K Sugino, BC Shields… - Neuron, 2016 - cell.com
Tissue and organ function has been conventionally understood in terms of the interactions
among discrete and homogeneous cell types. This approach has proven difficult in …
among discrete and homogeneous cell types. This approach has proven difficult in …
[PDF][PDF] Dissociable structural and functional hippocampal outputs via distinct subiculum cell classes
MS Cembrowski, MG Phillips, SF DiLisio, BC Shields… - Cell, 2018 - cell.com
The mammalian hippocampus, comprised of serially connected subfields, participates in
diverse behavioral and cognitive functions. It has been postulated that parallel circuitry …
diverse behavioral and cognitive functions. It has been postulated that parallel circuitry …
A repeated molecular architecture across thalamic pathways
…, J Winnubst, C Liu, V Valakh, L Wang, BC Shields… - Nature …, 2019 - nature.com
The thalamus is the central communication hub of the forebrain and provides the cerebral
cortex with inputs from sensory organs, subcortical systems and the cortex itself. Multiple …
cortex with inputs from sensory organs, subcortical systems and the cortex itself. Multiple …
Deconstructing behavioral neuropharmacology with cellular specificity
BC Shields, E Kahuno, C Kim, PF Apostolides, J Brown… - Science, 2017 - science.org
… Shields et al. developed an approach to deconstruct behavioral neuropharmacology with
cellular specificity. The technique, termed DART (drugs acutely restricted by tethering), uses …
cellular specificity. The technique, termed DART (drugs acutely restricted by tethering), uses …
[PDF][PDF] Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons
…, PR Melugin, KM Williford, SW Centanni, BC Shields… - Neuron, 2022 - cell.com
Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited
understanding of the molecular and experience-dependent mechanisms that regulate synaptic …
understanding of the molecular and experience-dependent mechanisms that regulate synaptic …
[HTML][HTML] A neuron-based screening platform for optimizing genetically-encoded calcium indicators
…, G Tsegaye, BF Fosque, R Behnam, BC Shields… - PloS one, 2013 - journals.plos.org
Fluorescent protein-based sensors for detecting neuronal activity have been developed
largely based on non-neuronal screening systems. However, the dynamics of neuronal state …
largely based on non-neuronal screening systems. However, the dynamics of neuronal state …
Noradrenergic signaling disengages feedforward transmission in the nucleus accumbens shell
…, BC Coleman, CA Grueter, BC Shields… - Journal of …, 2021 - Soc Neuroscience
The nucleus accumbens shell (NAcSh) receives extensive monoaminergic input from multiple
midbrain structures. However, little is known how norepinephrine (NE) modulates NAc …
midbrain structures. However, little is known how norepinephrine (NE) modulates NAc …
An open-source transparent microelectrode array
IA Weaver, AW Li, BC Shields… - Journal of neural …, 2022 - iopscience.iop.org
Objective. The micro-electrode array (MEA) is a cell-culture surface with integrated electrodes
used for assays of electrically excitable cells and tissues. MEAs have been a workhorse in …
used for assays of electrically excitable cells and tissues. MEAs have been a workhorse in …