User profiles for B. D. Gregory

Brian D. Gregory

Professor of Biology, University of Pennsylavania
Verified email at sas.upenn.edu
Cited by 13086

Next is now: new technologies for sequencing of genomes, transcriptomes, and beyond

R Lister, BD Gregory, JR Ecker - Current opinion in plant biology, 2009 - Elsevier
The sudden availability of DNA sequencing technologies that rapidly produce vast amounts
of sequence information has triggered a paradigm shift in genomics, enabling massively …

[HTML][HTML] Highly integrated single-base resolution maps of the epigenome in Arabidopsis

R Lister, RC O'Malley, J Tonti-Filippini, BD Gregory… - Cell, 2008 - cell.com
Deciphering the multiple layers of epigenetic regulation that control transcription is critical to
understanding how plants develop and respond to their environment. Using sequencing-by-…

The conservation and function of RNA secondary structure in plants

…, SJ Anderson, SW Foley, BD Gregory - Annual review of …, 2016 - annualreviews.org
… We thank the members of the Gregory lab for their helpful discussions. This work was
funded by the National Science Foundation (Career Award MCB-1053846 and grants MCB-…

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

…, TS Rai, T McBryan, BD Gregory… - Genes & …, 2013 - genesdev.cshlp.org
Senescence is a stable proliferation arrest, associated with an altered secretory pathway,
thought to promote tumor suppression and tissue aging. While chromatin regulation and lamin …

[HTML][HTML] A link between RNA metabolism and silencing affecting Arabidopsis development

BD Gregory, RC O'Malley, R Lister, MA Urich… - Developmental cell, 2008 - cell.com
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are abundant endogenous
small RNAs (smRNAs) that control transcript expression through posttranscriptional gene …

[HTML][HTML] Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

…, J Ma, SJ Anderson, NA Leu, Y Xu, BD Gregory… - PLoS …, 2018 - journals.plos.org
The N 6 -methyladenosine (m 6 A) modification is the most prevalent internal RNA modification
in eukaryotes. The majority of m 6 A sites are found in the last exon and 3’ UTRs. Here …

[HTML][HTML] Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome

JA Chekanova, BD Gregory, SV Reverdatto, H Chen… - Cell, 2007 - cell.com
The exosome complex plays a central and essential role in RNA metabolism. However,
comprehensive studies of exosome substrates and functional analyses of its subunits are lacking…

[PDF][PDF] Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle

…, ED Tichy, JG Davis, F Mourkioti, BD Gregory… - Cell metabolism, 2016 - cell.com
NAD is an obligate co-factor for the catabolism of metabolic fuels in all cell types. However,
the availability of NAD in several tissues can become limited during genotoxic stress and the …

The Arabidopsis dwf7/ste1 Mutant Is Defective in the Δ7 Sterol C-5 Desaturation Step Leading to Brassinosteroid Biosynthesis

…, S Fujioka, S Takatsuto, CP Tissier, BD Gregory… - The Plant …, 1999 - academic.oup.com
Lesions in brassinosteroid (BR) biosynthetic genes result in characteristic dwarf phenotypes
in plants. Understanding the regulation of BR biosynthesis demands continued isolation …

The Arabidopsis dwarf1 Mutant Is Defective in the Conversion of 24-Methylenecholesterol to Campesterol in Brassinosteroid Biosynthesis

S Choe, BP Dilkes, BD Gregory, AS Ross… - Plant …, 1999 - academic.oup.com
Since the isolation and characterization of dwarf1-1 (dwf1-1) from a T-DNA insertion mutant
population, phenotypically similar mutants, including deetiolated2 (det2),constitutive …