User profiles for B. D. Gregory
Brian D. GregoryProfessor of Biology, University of Pennsylavania Verified email at sas.upenn.edu Cited by 13086 |
Next is now: new technologies for sequencing of genomes, transcriptomes, and beyond
The sudden availability of DNA sequencing technologies that rapidly produce vast amounts
of sequence information has triggered a paradigm shift in genomics, enabling massively …
of sequence information has triggered a paradigm shift in genomics, enabling massively …
[HTML][HTML] Highly integrated single-base resolution maps of the epigenome in Arabidopsis
Deciphering the multiple layers of epigenetic regulation that control transcription is critical to
understanding how plants develop and respond to their environment. Using sequencing-by-…
understanding how plants develop and respond to their environment. Using sequencing-by-…
The conservation and function of RNA secondary structure in plants
…, SJ Anderson, SW Foley, BD Gregory - Annual review of …, 2016 - annualreviews.org
… We thank the members of the Gregory lab for their helpful discussions. This work was
funded by the National Science Foundation (Career Award MCB-1053846 and grants MCB-…
funded by the National Science Foundation (Career Award MCB-1053846 and grants MCB-…
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
…, TS Rai, T McBryan, BD Gregory… - Genes & …, 2013 - genesdev.cshlp.org
Senescence is a stable proliferation arrest, associated with an altered secretory pathway,
thought to promote tumor suppression and tissue aging. While chromatin regulation and lamin …
thought to promote tumor suppression and tissue aging. While chromatin regulation and lamin …
[HTML][HTML] A link between RNA metabolism and silencing affecting Arabidopsis development
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are abundant endogenous
small RNAs (smRNAs) that control transcript expression through posttranscriptional gene …
small RNAs (smRNAs) that control transcript expression through posttranscriptional gene …
[HTML][HTML] Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
…, J Ma, SJ Anderson, NA Leu, Y Xu, BD Gregory… - PLoS …, 2018 - journals.plos.org
The N 6 -methyladenosine (m 6 A) modification is the most prevalent internal RNA modification
in eukaryotes. The majority of m 6 A sites are found in the last exon and 3’ UTRs. Here …
in eukaryotes. The majority of m 6 A sites are found in the last exon and 3’ UTRs. Here …
[HTML][HTML] Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome
JA Chekanova, BD Gregory, SV Reverdatto, H Chen… - Cell, 2007 - cell.com
The exosome complex plays a central and essential role in RNA metabolism. However,
comprehensive studies of exosome substrates and functional analyses of its subunits are lacking…
comprehensive studies of exosome substrates and functional analyses of its subunits are lacking…
[PDF][PDF] Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle
NAD is an obligate co-factor for the catabolism of metabolic fuels in all cell types. However,
the availability of NAD in several tissues can become limited during genotoxic stress and the …
the availability of NAD in several tissues can become limited during genotoxic stress and the …
The Arabidopsis dwf7/ste1 Mutant Is Defective in the Δ7 Sterol C-5 Desaturation Step Leading to Brassinosteroid Biosynthesis
…, S Fujioka, S Takatsuto, CP Tissier, BD Gregory… - The Plant …, 1999 - academic.oup.com
Lesions in brassinosteroid (BR) biosynthetic genes result in characteristic dwarf phenotypes
in plants. Understanding the regulation of BR biosynthesis demands continued isolation …
in plants. Understanding the regulation of BR biosynthesis demands continued isolation …
The Arabidopsis dwarf1 Mutant Is Defective in the Conversion of 24-Methylenecholesterol to Campesterol in Brassinosteroid Biosynthesis
Since the isolation and characterization of dwarf1-1 (dwf1-1) from a T-DNA insertion mutant
population, phenotypically similar mutants, including deetiolated2 (det2),constitutive …
population, phenotypically similar mutants, including deetiolated2 (det2),constitutive …