User profiles for B. E. Engelhardt
 | Barbara EngelhardtSenior Investigator, Gladstone Institutes and Professor, Stanford University Verified email at stanford.edu Cited by 15233 |
Understanding mechanisms underlying human gene expression variation with RNA sequencing
Understanding the genetic mechanisms underlying natural variation in gene expression is a
central goal of both medical and evolutionary genetics, and studies of expression …
central goal of both medical and evolutionary genetics, and studies of expression …
The impact of sex on gene expression across human tissues
INTRODUCTION Many complex human phenotypes, including diseases, exhibit sex-differentiated
characteristics. These sex differences have been variously attributed to hormones, …
characteristics. These sex differences have been variously attributed to hormones, …
[PDF][PDF] A quantitative proteome map of the human body
Determining protein levels in each tissue and how they compare with RNA levels is important
for understanding human biology and disease as well as regulatory processes that control …
for understanding human biology and disease as well as regulatory processes that control …
How algorithmic confounding in recommendation systems increases homogeneity and decreases utility
Recommendation systems are ubiquitous and impact many domains; they have the
potential to influence product consumption, individuals' perceptions of the world, and life-altering …
potential to influence product consumption, individuals' perceptions of the world, and life-altering …
Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder
Importance Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for …
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for …
Measuring the predictability of life outcomes with a scientific mass collaboration
…, J Brooks-Gunn, BE Engelhardt… - Proceedings of the …, 2020 - National Acad Sciences
How predictable are life trajectories? We investigated this question with a scientific mass
collaboration using the common task method; 160 teams built predictive models for six life …
collaboration using the common task method; 160 teams built predictive models for six life …
[PDF][PDF] Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease
Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …
A statin-dependent QTL for GATM expression is associated with statin-induced myopathy
Statins are prescribed widely to lower plasma low-density lipoprotein (LDL) concentrations
and cardiovascular disease risk 1 and have been shown to have beneficial effects in a broad …
and cardiovascular disease risk 1 and have been shown to have beneficial effects in a broad …
[HTML][HTML] Alignment of spatial genomics data using deep Gaussian processes
Spatially resolved genomic technologies have allowed us to study the physical organization
of cells and tissues, and promise an understanding of local interactions between cells. …
of cells and tissues, and promise an understanding of local interactions between cells. …
[HTML][HTML] Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements
Background Recent assays for individual-specific genome-wide DNA methylation profiles
have enabled epigenome-wide association studies to identify specific CpG sites associated …
have enabled epigenome-wide association studies to identify specific CpG sites associated …