Fragile X syndrome (FXS) is the most common inherited form of mental retardation and a
leading genetic cause of autism. There is increasing evidence in both FXS and other forms of …

Local or dendritic protein synthesis is required for long-term functional synaptic change, such
as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on …

One of the most striking features of the hippocampal network is its ability to self‐generate
neuronal sequences representing temporally compressed, spatially coherent paths. These …

Effective navigation requires planning extended routes to remembered goal locations.
Hippocampal place cells have been proposed to have a role in navigational planning, but direct …

Salient stimuli that modify behavior induce transcription of activity-regulated cytoskeleton-associated
protein (Arc/Arg3.1) and transport Arc mRNA into dendrites, suggesting that local …

Hippocampal replays are episodes of sequential place cell activity during sharp-wave ripple
oscillations (SWRs). Conflicting hypotheses implicate awake replay in learning from reward …

The mevalonate pathway produces cholesterol and nonsterol isoprenoids, such as
geranylgeraniol. In the brain, a fraction of cholesterol is metabolized in neurons by the enzyme …

Cerebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs);
however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain …

Neuronal circuits produce self-sustaining sequences of activity patterns, but the precise
mechanisms remain unknown. Here we provide evidence for autoassociative dynamics in …

Fragile X syndrome, as well as other forms of mental retardation and autism, is associated
with altered dendritic spine number and structure. Fragile X syndrome is caused by loss-of-…