Pulmonary drug delivery serves two purposes, namely the application of locally active
compounds for treatment of diseases afflicting the lung, and the utilization of the pulmonary …

The close interaction between organic chemi stry and biology goes back to the late 18th
century, when the modern natural sciences began to take shape. After synthetic organic …

DNA double-strand break (DSB) repair by nonhomologous end joining (NHEJ) requires the
assembly of several proteins on DNA ends. Although biochemical studies have elucidated …

Activity-based protein profiling (ABPP) is one of the main driving forces in chemical biology
and one of the most visible areas where organic chemistry contributes to chemical biology …

Quaternized modifications of chitosan present characteristics that might be useful in DNA
condensing and efficient gene delivery. Trimethylated chitosan (TMO) was synthesized from …

A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to
the death of one volunteer and produced mild-to-severe neurological symptoms in four others…

In the present study, we evaluated polyethylenimine (PEI) of different molecular weights (MWs)
as a DNA complexing agent for its efficiency in transfecting nondifferentiated COS-1 (…

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal
storage disorder. Carriership for Gaucher disease has recently been identified as major risk …

Polarized segregation of proteins in T cells is thought to play a role in diverse cellular functions
including signal transduction, migration, and directed secretion of cytokines. Persistence …

The proteasome is an essential evolutionary conserved protease involved in many
regulatory systems. Here, we describe the synthesis and characterization of the activity-based, …