Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

Background: Youths with bipolar disorder are ideal for studying illness pathophysiology
given their early presentation, lack of extended treatment, and high genetic loading. Adult …

OBJECTIVE: Psychotic affective disorders are the most prevalent idiopathic psychoses, but
their outcome from onset has rarely been studied. In this study, the authors determined the …

• To test the validity of theDSM-IIIdiagnosis of borderline personality disorder (BPD), we
examined the phenomenology, family history, treatment response, and four-to-seven-year long-…

• The clinical use of antipsychotic agents may be enhanced by considering their dose-effect
characteristics. In particular, assessment of immediate and later follow-up treatment of …

Endogenous opioids seem to play a critical role in the regulation of mood states. For example,
there is accumulating evidence that stimulation of κ-opioid receptors, upon which the …

The default-mode network (DMN) consists of a set of brain areas preferentially activated during
internally focused tasks. We used functional magnetic resonance imaging (fMRI) to study …

BackgroundNeurocognitive dysfunction in schizophrenia (SZ), bipolar (BD) and related
disorders represents a core feature of these illnesses, possibly a marker of underlying …

We report the implantation of patient-derived midbrain dopaminergic progenitor cells,
differentiated in vitro from autologous induced pluripotent stem cells (iPSCs), in a patient with …