DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …

ClpXP and other AAA+ proteases recognize, mechanically unfold, and translocate target
proteins into a chamber for proteolysis. It is not known whether these remarkable molecular …

ClpXP is an ATP-dependent protease in which the ClpX AAA+ motor binds, unfolds, and
translocates specific protein substrates into the degradation chamber of ClpP. We present cryo-…

ClpX, a AAA+ ring homohexamer, uses the energy of ATP binding and hydrolysis to power
conformational changes that unfold and translocate target proteins into the ClpP peptidase for …

Liquid-ordered (Lo) and liquid-disordered (Ld) phase coexistence has been suggested to
partition the plasma membrane of biological cells into lateral compartments, allowing for …

… Stinson et al. demonstrate that DNA end processing during non-homologous end joining (NHEJ)
occurs only after DNA ends are aligned for ligation. This mechanism minimizes errors …

The hexameric AAA+ ring of Escherichia coli ClpX, an ATP-dependent machine for protein
unfolding and translocation, functions with the ClpP peptidase to degrade target substrates. …

Escherichia coli ClpXP is one of the most thoroughly studied AAA+ proteases, but relatively
little is known about the reactions that allow it to bind and then engage specific protein …

Nonhomologous end joining (NHEJ), the primary pathway of vertebrate DNA double-strand-break
(DSB) repair, directly re-ligates broken DNA ends. Damaged DSB ends that cannot be …

A novel integrated pilot-scale A-stage high rate activated sludge, B-stage short-cut biological
nitrogen removal and side-stream enhanced biological phosphorus removal (A/B-shortcut N…