… The life spans of various long-lived daf strains in axenic (JR Vanfleteren, BP Braeckman,
unpublished data) and monoxenic (derived from the literature) culture are shown in Table 1, …

The integration of the rate-of-living and oxidative damage theory of aging predicts that lifespan
extension is linked to low energy metabolism, low ROS production rates, low molecular …

Accurate measures of physiological and metabolic condition could provide more insight into
how longevity genes and signalling pathways affect global metabolic activity and life span. …

The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes
mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear. …

Dietary restriction (DR) increases life span in a wide variety of animals. In Caenorhabditis
elegans both reduced bacterial concentration (BDR) and culture on non-bacterial, semi-…

Culture in axenic medium causes two-fold increases in the length of development and adult
life span in Caenorhabditis elegans. We asked whether axenic medium imposes dietary …

… or treated for 24 hr with the indicated concentrations of BP. (F) Kaplan-Meier survival analysis
… against frh-1 (frh-1 RNAi), and left untreated or treated from eggs with 10 mM BP, is shown. …

The superoxide free radical (O 2 •− ) has been viewed as a likely major contributor to aging.
If this is correct, then superoxide dismutase (SOD), which removes O 2 •− , should contribute …

Dietary restriction (DR) is the most consistent means of extending life span throughout the
animal kingdom. Multiple mechanisms by which DR may act have been proposed but none …

For cells the passage from life to death can involve a regulated, programmed transition. In
contrast to cell death, the mechanisms of systemic collapse underlying organismal death …