… Because this is the first time top-down proteomics has been achieved at this scale, an early
glimpse at the prevalence of uncharacterized mass shifting events has been revealed in the …

The top-down approach to proteomics offers compelling advantages due to the potential to
provide complete characterization of protein sequence and post-translational modifications. …

ProSight PTM 2.0 ( http://prosightptm2.scs.uiuc.edu ) is the next generation of the ProSight
PTM web-based system for the identification and characterization of proteins using top down …

Many top‐down proteomics experiments focus on identifying and localizing PTMs and other
potential sources of “mass shift” on a known protein sequence. A simple application to …

Top-down proteomics is emerging as a viable method for the routine identification of hundreds
to thousands of proteins. In this work we report the largest top-down study to date, with the …

We developed a method for restricted enzymatic proteolysis using the outer membrane
protease T (OmpT) to produce large peptides (>6.3 kDa on average) for mass spectrometry–…

… 3e) is consistent with the encapsulation of 1 average-length DNA (900 bp) and mRNA (500
nt) … The incorporation of the average-length DNA strand (375 bp) matches the higher mass …

This article explores moral injury, a concept from military mental health professionals, which
refers to the emotional effects on soldiers of actions taken as part of their military obligations …

Pilot Project #1—the identification and characterization of human histone H 4 proteoforms by
top‐down MS —is the first project launched by the C onsortium for T op‐ D own P roteomics …

… One value proposition is that proteoform discovery and validation will provide robust,
protein-based biomarkers that can detect disease early and guide the development of therapeutics …