[HTML][HTML] The diversity of ribonuclease P: protein and RNA catalysts with analogous biological functions
Ribonuclease P (RNase P) is an essential endonuclease responsible for catalyzing 5’ end
maturation in precursor transfer RNAs. Since its discovery in the 1970s, RNase P enzymes …
maturation in precursor transfer RNAs. Since its discovery in the 1970s, RNase P enzymes …
[HTML][HTML] Beam image-shift accelerated data acquisition for near-atomic resolution single-particle cryo-electron tomography
…, J da Fonseca Rezende e Mello, BP Klemm… - Nature …, 2021 - nature.com
Tomographic reconstruction of cryopreserved specimens imaged in an electron microscope
followed by extraction and averaging of sub-volumes has been successfully used to derive …
followed by extraction and averaging of sub-volumes has been successfully used to derive …
[HTML][HTML] Mechanistic studies reveal similar catalytic strategies for phosphodiester bond hydrolysis by protein-only and RNA-dependent ribonuclease P
Ribonuclease P (RNase P) is an endonuclease that catalyzes the essential removal of the 5′
end of tRNA precursors. Until recently, all identified RNase P enzymes were a …
end of tRNA precursors. Until recently, all identified RNase P enzymes were a …
Differential substrate recognition by isozymes of plant protein-only Ribonuclease P
Ribonuclease P (RNase P) catalyzes the cleavage of leader sequences from precursor tRNA
(pre-tRNA). Typically, these enzymes are ribonucleic protein complexes that are found in …
(pre-tRNA). Typically, these enzymes are ribonucleic protein complexes that are found in …
[HTML][HTML] High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP
BP Klemm, AP Sikkema, AL Hsu, JC Horng… - Journal of Biological …, 2022 - ASBMB
Deoxynucleoside triphosphate (dNTP) triphosphohydrolases (dNTPases) are important
enzymes that may perform multiple functions in the cell, including regulating the dNTP pools and …
enzymes that may perform multiple functions in the cell, including regulating the dNTP pools and …
RNase P enzymes: divergent scaffolds for a conserved biological reaction
Ribonuclease P (RNase P) catalyzes the maturation of the 5′ end of precursor-tRNAs (pre-tRNA)
and is conserved in all domains of life. However, the composition of RNase P varies …
and is conserved in all domains of life. However, the composition of RNase P varies …
Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P
BP Klemm, A Karasik, KJ Kaitany, A Shanmuganathan… - Rna, 2017 - rnajournal.cshlp.org
Protein-only ribonuclease P (PRORP) is an enzyme responsible for catalyzing the 5′ end
maturation of precursor transfer ribonucleic acids (pre-tRNAs) encoded by various cellular …
maturation of precursor transfer ribonucleic acids (pre-tRNAs) encoded by various cellular …
Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase
BP Klemm, D Singh, CE Smith… - Proceedings of the …, 2022 - National Acad Sciences
Levels of the cellular dNTPs, the direct precursors for DNA synthesis, are important for DNA
replication fidelity, cell cycle control, and resistance against viruses. Escherichia coli …
replication fidelity, cell cycle control, and resistance against viruses. Escherichia coli …
Kinetic mechanism of human mitochondrial RNase P
X Liu, N Wu, A Shanmuganathan, BP Klemm… - bioRxiv, 2019 - biorxiv.org
A first step in processing mitochondrial precursor tRNA (pre-tRNA) is cleavage of the 5’ leader
catalyzed by ribonuclease P (RNase P). Human mitochondrial RNase P (mtRNase P) is …
catalyzed by ribonuclease P (RNase P). Human mitochondrial RNase P (mtRNase P) is …
Phenomenological model of the copper oxide superconductors
RA Klemm - Physical Review B, 1990 - APS
We propose a phenomenological model for the copper oxide superconductors in which one
complex s-wave order parameter (OP) is associated with each of the N conducting layers …
complex s-wave order parameter (OP) is associated with each of the N conducting layers …