Background Cleft lip and/or palate (CL/P) is one of the most common birth conditions in the
world, but little is known about its causes. Professional opinion remains divided as to which …

Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …

Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of complex …

Through genome-wide association meta-analyses of up to 133,010 individuals of European
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are
highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other …

Purpose.: Timespent in “sports/outdoor activity” has shown a negative association with incident
myopia during childhood. We investigated the association of incident myopia with time …

Refractive error is the most common eye disorder worldwide and is a prominent cause of
blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The …

Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the
general population, but the effects of this risk are unclear in people not ascertained for …