Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the neural …

Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss
of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic …

Retinitis Pigmentosa (RP) in the human is a progressive, currently irreversible neural degenerative
disease usually caused by gene defects that disrupt the function or architecture of the …

Toll-like receptor 2 (TLR2) agonists induce a subset of TLR4-inducible proinflammatory
genes, which suggests the use of differential signaling pathways. Murine macrophages …

Amyloid β 1−42 (Aβ 1 - 42 ) is a self-associating peptide that becomes neurotoxic upon
aggregation. Toxicity originally was attributed to the presence of large, readily formed Aβ fibrils, …

Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It
has long been assumed that the surviving neural retina is largely resistant to this sensory …

We previously reported that gram-negative bacterial lipopolysaccharide (LPS) activates
cells via Toll-like receptor (TLR) 4, whereas the mycobacterial cell wall glycolipid …

We previously showed that viable Mycobacterium tuberculosis (Mtb) bacilli contain distinct
ligands that activate cells via the mammalian Toll-like receptor (TLR) proteins TLR2 and TLR4…

Purpose Our objective was to comprehensively assess the nature and chronology of neural
remodeling in retinal degenerations triggered by light-induced retinal damage (LIRD) in …

purpose. Early visual defects in degenerative diseases such as retinitis pigmentosa (RP)
may arise from phased remodeling of the neural retina. The authors sought to explore the …