… Neuman, unpublished data) suggesting that networks formed of dimers may be an ancestral
trait that originated in the hypothetical proto-M. M has many of the characteristics that would …

The present outbreak of lower respiratory tract infections, including respiratory distress
syndrome, is the third spillover, in only two decades, of an animal coronavirus to humans …

The M protein of coronavirus plays a central role in virus assembly, turning cellular membranes
into workshops where virus and host factors come together to make new virus particles. …

… (a) Cryoelectron tomograph of virus particles in water ice (courtesy of Ben Neuman). Virions
are around 85 nm in diameter. (b) Schematic illustration of a particle of mouse hepatitis virus…

The 5′ cap structures of higher eukaryote mRNAs have ribose 2′-O-methylation. Likewise,
many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-…

The cellular uptake of PMOs (phosphorodiamidate morpholino oligomers) can be enhanced
by their conjugation to arginine-rich CPPs (cell-penetrating peptides). Here, we discuss our …

Coronavirus particles are enveloped and pleomorphic and are thus refractory to crystallization
and symmetry-assisted reconstruction. A novel methodology of single-particle image …

Coronaviruses (CoV), like other positive-stranded RNA viruses, redirect and rearrange host
cell membranes for use as part of the viral genome replication and transcription machinery. …

Severe acute respiratory syndrome (SARS) coronavirus infection and growth are dependent
on initiating signaling and enzyme actions upon viral entry into the host cell. Proteins …

The crystal structure of a conserved domain of nonstructural protein 3 (nsP3) from severe
acute respiratory syndrome coronavirus (SARS-CoV) has been solved by single-wavelength …