User profiles for B. Cuypers

Bart Cuypers

Senior Data Scientist - Immune Informatics at GSK
Verified email at gsk.com
Cited by 1560

[HTML][HTML] Tackling drug resistance and other causes of treatment failure in Leishmaniasis

…, F Dumetz, L Dirkx, D Bulté, B Cuypers… - Frontiers in Tropical …, 2022 - frontiersin.org
… In clinical practice, no resistance has yet been observed for the repurposed antifungal
amphotericin B (AmB) and the repurposed aminoglycoside antibiotic paromomycin (PM), but AmB…

Nanopore sequencing for mycobacterium tuberculosis: A critical review of the literature, new developments, and future opportunities

…, M Grobbelaar, S Oostvogels, B Cuypers… - Journal of clinical …, 2022 - Am Soc Microbiol
The next-generation, short-read sequencing technologies that generate comprehensive,
whole-genome data with single nucleotide resolution have already advanced tuberculosis …

[HTML][HTML] LC-MS metabolomics from study design to data-analysis–using a versatile pathogen as a test case

M Berg, M Vanaerschot, A Jankevics, B Cuypers… - Computational and …, 2013 - Elsevier
Thanks to significant improvements in LC-MS technology, metabolomics is increasingly
used as a tool to discriminate the responses of organisms to various stimuli or drugs. In this …

[HTML][HTML] A community resource for paired genomic and metabolomic data mining

…, JM Crawford, CR Currie, B Cuypers… - Nature Chemical …, 2021 - nature.com
Genomics and metabolomics are widely used to explore specialized metabolite diversity.
The Paired Omics Data Platform is a community initiative to systematically document links …

Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent

…, M Berg, G De Muylder, F Dumetz, B Cuypers… - Elife, 2016 - elifesciences.org
… from populations A and B, it is expected to be positive if A,B and C are related by a simple
history of divergence and genetic drift, but negative if admixture from A or B has contributed to …

Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression

…, P Pescher, M Vanaerschot, CJ Meehan, B Cuypers… - MBio, 2017 - Am Soc Microbiol
Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and
potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major …

[HTML][HTML] Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell …

…, J De Waele, C Hermans, H Lambrechts, B Cuypers… - Redox biology, 2021 - Elsevier
… Caspase-3/7 positive cells was calculated with the formula: G r e e n o b j e c t c o u n t R e
d o b j e c t c o u n t + G r e e n o b j e c t c o u n t − O v e r l a p p i n g o b j e c t c o u n t ∗ 100 . …

[HTML][HTML] Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through …

…, L Lachaud, J Cotton, M Sanders, B Cuypers… - PloS one, 2016 - journals.plos.org
… This patient had received several successive treatments with liposomal amphotericin B (AmB)
[18] and MIL (personal communication Lachaud). Species identification was done by …

On the feasibility of mining CD8+ T cell receptor patterns underlying immunogenic peptide recognition

N De Neuter, W Bittremieux, C Beirnaert, B Cuypers… - Immunogenetics, 2018 - Springer
… While it is not known whether any of these 56,023 control TCR sequences are capable of
recognizing either B*08-FLKEKGGL or B*08-EIYKRWII, the upper limit of the expected …

Relapse after treatment with miltefosine for visceral leishmaniasis is associated with increased infectivity of the infecting Leishmania donovani strain

…, B Cuypers, NR Bhattarai, S Uranw, M Berg, B Ostyn… - MBio, 2013 - Am Soc Microbiol
… The horizontal bars in panels A and B indicate the mean values for the groups. The broken
line in panel C indicates the cutoff to determine whether a strain is SSG sensitive or SSG …