User profiles for B. Cuypers
Bart CuypersSenior Data Scientist - Immune Informatics at GSK Verified email at gsk.com Cited by 1560 |
[HTML][HTML] Tackling drug resistance and other causes of treatment failure in Leishmaniasis
… In clinical practice, no resistance has yet been observed for the repurposed antifungal
amphotericin B (AmB) and the repurposed aminoglycoside antibiotic paromomycin (PM), but AmB…
amphotericin B (AmB) and the repurposed aminoglycoside antibiotic paromomycin (PM), but AmB…
Nanopore sequencing for mycobacterium tuberculosis: A critical review of the literature, new developments, and future opportunities
…, M Grobbelaar, S Oostvogels, B Cuypers… - Journal of clinical …, 2022 - Am Soc Microbiol
The next-generation, short-read sequencing technologies that generate comprehensive,
whole-genome data with single nucleotide resolution have already advanced tuberculosis …
whole-genome data with single nucleotide resolution have already advanced tuberculosis …
[HTML][HTML] LC-MS metabolomics from study design to data-analysis–using a versatile pathogen as a test case
Thanks to significant improvements in LC-MS technology, metabolomics is increasingly
used as a tool to discriminate the responses of organisms to various stimuli or drugs. In this …
used as a tool to discriminate the responses of organisms to various stimuli or drugs. In this …
[HTML][HTML] A community resource for paired genomic and metabolomic data mining
Genomics and metabolomics are widely used to explore specialized metabolite diversity.
The Paired Omics Data Platform is a community initiative to systematically document links …
The Paired Omics Data Platform is a community initiative to systematically document links …
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent
… from populations A and B, it is expected to be positive if A,B and C are related by a simple
history of divergence and genetic drift, but negative if admixture from A or B has contributed to …
history of divergence and genetic drift, but negative if admixture from A or B has contributed to …
Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression
Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and
potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major …
potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major …
[HTML][HTML] Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell …
…, J De Waele, C Hermans, H Lambrechts, B Cuypers… - Redox biology, 2021 - Elsevier
… Caspase-3/7 positive cells was calculated with the formula: G r e e n o b j e c t c o u n t R e
d o b j e c t c o u n t + G r e e n o b j e c t c o u n t − O v e r l a p p i n g o b j e c t c o u n t ∗ 100 . …
d o b j e c t c o u n t + G r e e n o b j e c t c o u n t − O v e r l a p p i n g o b j e c t c o u n t ∗ 100 . …
[HTML][HTML] Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through …
… This patient had received several successive treatments with liposomal amphotericin B (AmB)
[18] and MIL (personal communication Lachaud). Species identification was done by …
[18] and MIL (personal communication Lachaud). Species identification was done by …
On the feasibility of mining CD8+ T cell receptor patterns underlying immunogenic peptide recognition
… While it is not known whether any of these 56,023 control TCR sequences are capable of
recognizing either B*08-FLKEKGGL or B*08-EIYKRWII, the upper limit of the expected …
recognizing either B*08-FLKEKGGL or B*08-EIYKRWII, the upper limit of the expected …
Relapse after treatment with miltefosine for visceral leishmaniasis is associated with increased infectivity of the infecting Leishmania donovani strain
… The horizontal bars in panels A and B indicate the mean values for the groups. The broken
line in panel C indicates the cutoff to determine whether a strain is SSG sensitive or SSG …
line in panel C indicates the cutoff to determine whether a strain is SSG sensitive or SSG …