The C‐type lectin DC‐SIGN (CD209) is an antigen‐uptake receptor for Candida albicans on dendritic cells

…, IJM de Vries, R Torensma, B Joosten… - European journal of …, 2003 - Wiley Online Library
Dendritic cells (DC) that express the type II C‐type lectin DC‐SIGN (CD209) are located in
the submucosa of tissues, where they mediate HIV‐1 entry. Interestingly, the pathogen …

Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti–DC-SIGN antibody

PJ Tacken, IJM de Vries, K Gijzen, B Joosten, D Wu… - Blood, 2005 - ashpublications.org
Current dendritic cell (DC)–based vaccines are based on ex vivo–generated autologous DCs
loaded with antigen prior to readministration into patients. A more direct and less laborious …

Targeted PLGA nano-but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

LJ Cruz, PJ Tacken, R Fokkink, B Joosten… - Journal of Controlled …, 2010 - Elsevier
Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine components
to dendritic cells (DCs), which are professional antigen presenting cells. However, the …

Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells

…, NM Van Maarseveen, M Nijhuis, B Joosten… - The Journal of cell …, 2004 - rupress.org
The C-type lectin dendritic cell (DC)–specific intercellular adhesion molecule grabbing non-integrin
(DC-SIGN; CD209) facilitates binding and internalization of several viruses, …

Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion

…, A Cambi, M Koopman, B Joosten… - Proceedings of the …, 2009 - National Acad Sciences
… FWHM, with a localization accuracy of σ approximately ω/(S/B) where ω is the width of the
Gaussian fit to the intensity profile and S/B is the signal-to-background of individual spots (33). …

Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells

AW Zimmerman, B Joosten, R Torensma, JR Parnes… - Blood, 2006 - ashpublications.org
… CD6 is a surface receptor expressed by T lymphocytes, thymocytes, and a subset of B cells.
Its extracellular region … We detected low levels of ALCAM on B cells but not on NK cells. …

DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production

F Meyer-Wentrup, A Cambi, B Joosten… - Journal of Leucocyte …, 2009 - academic.oup.com
C-type lectin receptors (CLRs) expressed on APCs play a pivotal role in the immune system
as pattern-recognition and antigen-uptake receptors. In addition, they may signal directly, …

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

E Lubberts, B Joosten, J van de Loo… - Inflammation …, 2002 - search.proquest.com
… [5] Lubberts E, Joosten LAB, Chabaud M, Van den Bersselaar, Oppers B, Coenen-de
Roo CJJ et al. Local interleukin-4 gene therapy in murine collagen arthritis suppresses IL-17 …

[HTML][HTML] Optimization of procedural sedation and analgesia during atrial fibrillation ablation

…, EAC Bouman, BAJ Joosten - Current Opinion in …, 2023 - journals.lww.com
An optimal sedation strategy during AF ablation should be based on AF patient characteristics,
the level of sedation needed, the procedure (duration and type of ablation) and the …

Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation

…, W Ginter, L Berod, LJ Cruz, B Joosten… - Blood, The Journal …, 2011 - ashpublications.org
… (B) Immature DCs were incubated with antineck antibody H200 or DCN46 (green) at 4C,
washed, and shifted to 37C for 2 hours. After fixation and permeabilization, the CD63+ …