… CAGGIULA A, ENGLAND B, GREENE T, HUNSICKER L, KUSEK J, ROGERS N, TESCHAN
P, FOR THE MDRD STUDY GRoUP: Effects of dietary protein restriction on the progression …

Chronic renal failure (CRF) is associated with negative nitrogen balance and loss of lean body
mass. To identify specific proteolytic pathways activated by CRF, protein degradation was …

Patients with advanced renal disease randomized to the very low-protein diet group in the
Modification of Diet in Renal Disease (MDRD) Study had a marginally (P = 0.066) slower …

… Radionucleotides were purchased from New England Nuclear (Boston, MA), guanidinium
… Bailey, and BK England. 1992. Chronic metabolic acidosis accelerates whole body …

In normal subjects and diabetic patients, insulin suppresses whole body proteolysis
suggesting that the loss of lean body mass and muscle wasting in insulinopenia is related to …

Importance Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of ALS characterized
by age of symptom onset less than 25 years and a variable presentation. Objective To …

In rat muscle metabolic acidosis increases ATP-dependent protein degradation and levels
of mRNAs for ubiquitin (Ub) and proteasome subunits. Because adrenalectomy (ADX) …

An early response to metabolic acidosis is an increase in the degradation of muscle protein
to provide the nitrogen needed to increase glutamine production so the kidney can excrete …

Anorexia and/or a protein- and calorie-restricted diet can cause protein wasting by limiting
the intake of essential amino acids (EAA) and, hence, protein synthesis. By this mechanism …

Metabolic acidosis impairs protein and amino acid metabolism in rat muscle. To examine how
extracellular acidification affects cellular protein turnover, we studied the BC3H1 myocyte. …