Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II)
signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH…

During angiogenesis, nascent vascular sprouts fuse to form vascular networks, enabling
efficient circulation. Mechanisms that stabilize the vascular plexus are not well understood. …

… In addition, several peripheral organs and cell types express LRRK2 including kidney, lung
and B cells suggesting that LRRK2 mutations may impact physiological processes and exert …

… Ex vivo chemotaxis assay using unsorted T and B cells from WT or Sphk2 knockout mice
treated for 24 hours with FTY720 (A) or for 6 or 24 hours with FTY720-P (B) (1 mg/kg …

LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and
promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the liver…

… Our results show that all well known GABA B responses relate to heteromeric GABA B(1,2) …
B responses in hippocampal slices of GABA B(2) -deficient mice, indicating that GABA B(1) …

Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …

The functional interaction between fibroblast growth factor 23 (FGF‐23) and Klotho in the
control of vitamin D and phosphate homeostasis is manifested by the largely overlapping …

We identified previously in vitro LRP4 (low-density lipoprotein receptor-related protein 4) as
a facilitator of the WNT (Wingless-type) antagonist sclerostin and found mutations disrupting …

… However, the relative contributions of these two different activities to T and B cell function …
zone B cells, B1 B cells, IL-10–producing B cells, regulatory T cells, and mature T and B cells. …