[HTML][HTML] Exploiting the Potential of Drosophila Models in Lysosomal Storage Disorders: Pathological Mechanisms and Drug Discovery

L Rigon, C De Filippis, B Napoli, R Tomanin, G Orso - Biomedicines, 2021 - mdpi.com
… and dGBA1a,b double mutant: only dGBA1a flies showed a significantly increased survival
compared with control flies, whereas dGBA1b mutant and dGBA1a,b double mutant showed …

[HTML][HTML] Concentrations of cytokines IL-6 and IL-10 in plasma of burn patients: their relationship to sepsis and outcome

…, V Cataldo, R Mogavero, B Napoli… - Annals of burns and …, 2008 - ncbi.nlm.nih.gov
Burn injury induces a suppression of the Th1 response, which is associated with an increased
susceptibility to conditions of infection, morbidity, and mortality. It is well established that …

Circulating dendritic cells following burn

…, V Cataldo, R Mogavero, C Lombardo, B Napoli… - Burns, 2009 - Elsevier
Burns are associated with immune suppression and subsequent development of sepsis.
Dendritic cells (DCs) are potent antigen-presenting cells that serve as a critical link between the …

Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegia

C Vantaggiato, G Orso, G Guarato, F Brivio, B Napoli… - Brain, 2023 - academic.oup.com
… (B) SPG15 cells were incubated with the indicated compounds at the concentration of 10
μM for 24 h (except of pimozide, 20 μM). Amiodarone, an L-type calcium channel antagonist …

[HTML][HTML] Naringenin ameliorates Drosophila ReepA hereditary spastic paraplegia-linked phenotypes

B Napoli, S Gumeni, A Forgiarini, M Fantin… - Frontiers in …, 2019 - frontiersin.org
… (B) ReepA E relative gene expression in young (1 day) and old (30 days) control (ReepA
+C591 /ReepA +C591 ) flies raised on standard food. Significance was calculated by using two-…

Reduction of plasma granzyme A correlates with severity of sepsis in burn patients

…, N D'arpa, R Mogavero, G Amato, V Cataldo, B Napoli… - Burns, 2010 - Elsevier
The risk of mortality is high in burn patients and correlates with age, burn area extent, and
sepsis. Immunosuppression has been reported to occur after severe burn. Cytotoxic cells …

Flavonoids Regulate Lipid Droplets Biogenesis in Drosophila melanogaster

M Fantin, F Garelli, B Napoli… - Natural Product …, 2019 - journals.sagepub.com
… Percentage of fat body cell cytoplasm occupied by LDs was calculated (b). Quantification
of LDs number (c) and diameter (d). (e) The results of the LDs’ size were plotted as box-and-…

[HTML][HTML] Drosophila D-idua Reduction Mimics Mucopolysaccharidosis Type I Disease-Related Phenotypes

C De Filippis, B Napoli, L Rigon, G Guarato, R Bauer… - Cells, 2021 - mdpi.com
… As shown in Figure 8B, expression of glycolytic enzymes was increased 3-fold in our D-idua
model compared to control, suggesting the induction of glycolytic flux. As expected, …

[HTML][HTML] Burns in pregnancy

B Napoli, N D'ARPA, M Masellis… - Annals of Burns and Fire …, 2000 - medbc.com
Two cases are reported of bums in pregnancy. After a survey of the literature and a discussion
of the incidence of bums in pregnancy, the physiopathology of spontaneous uterine …

[HTML][HTML] Staphylococcal scalded skin syndrome: Criteria for differential diagnosis from Lyell's syndrome. Two cases in adult patients

B Napoli, N D'Arpa, L D'Amelio, S Chimenti… - Annals of Burns and …, 2006 - ncbi.nlm.nih.gov
A review of the relative international literature of the last few years is followed by a description
of two cases of staphylococcal scalded skin syndrome in adults. As in both cases the initial …