The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that
controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process is …

… While NF-KB activity is constitutively high in mature B cells and in some T cell lines, most
cells lack constitutive NF-KB-binding activity. In these cells, NF-KB is strongly induced by …

Adequate control of HIV requires impairing the infection, replication and spread of the virus,
no small task given the extraordinary capacity of HIV to exploit the cell's molecular …

Human immunodeficiency virus-1 (HIV-1) gene expression is controlled by cellular transcription
factors and by virally encoded trans-activation proteins of the HIV-1 tat and art/trs genes, …

… 100; sizes are indicated schematically within B. The area of each black or gray sector is …
B, Schematic version of the output shown in A, with the positions of barriers indicated as thick …

The HIV accessory protein negative factor (Nef) is one of the earliest and most abundantly
expressed viral proteins. It is also found in the serum of infected individuals (Caby MP, Lankar …

To stimulate transcriptional elongation of HIV-1 genes, the transactivator Tat recruits the
positive transcription elongation factor b (P-TEFb) to the initiating RNA polymerase II (RNAPII). …

Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor that is in
clinical trials as a cancer treatment because of its antiproliferative properties. We found that the …

The elongation of transcription is a highly regulated process that requires negative and
positive effectors. By binding the double-stranded stem in the transactivation response (TAR) …

Recently, APOBEC3G has been identified as a host factor that blocks retroviral replication. It
introduces G to A hypermutations in newly synthesized minus strand viral cDNA at the step …