Epidemiological studies of the past decades have provided a strong body of evidence that
elevated levels of ambient particulate air pollution (PM) are associated with increased …

… 1 127 578), high density cholesterol (HDL) was measured after precipitation of the
apoprotein B-containing lipoproteins with phosphotungstate/Mg 2 + (Boehringer No. 543 00 4). …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels. …

… b, Consequential analysis for a causality analysis investigating whether DNA methylation
in blood at the sentinel CpG sites is the consequence of BMI. Units are change in methylation …

Objective— Interleukin (IL)-1β represents a key cytokine in the development of cardiovascular
disease (CVD). IL-1β is counter-regulated by IL-1 receptor antagonist (IL-1RA), an …

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum,
we conducted a meta-analysis of genome-wide association data from 26,676 T2D case …

Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian …

Background— C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …

Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …