[HTML][HTML] Ultrafast Sample placement on Existing tRees (UShER) enables real-time phylogenetics for the SARS-CoV-2 pandemic

Y Turakhia, B Thornlow, AS Hinrichs, N De Maio… - Nature …, 2021 - nature.com
b, UShER evaluations of the parsimony score for placing the sample S5 (blue) at each
possible position (Methods) of our example phylogeny (shown in a). We considered the branch …

[HTML][HTML] Pandemic-scale phylogenomics reveals the SARS-CoV-2 recombination landscape

Y Turakhia, B Thornlow, A Hinrichs, J McBroome… - Nature, 2022 - nature.com
… Specifically, we discover that the root of the B.1.355 lineage might have resulted from a
recombination event between nodes belonging to the B.1.595 and B.1.371 lineages (Fig. 3 and …

A daily-updated database and tools for comprehensive SARS-CoV-2 mutation-annotated trees

J McBroome, B Thornlow, AS Hinrichs… - Molecular biology …, 2021 - academic.oup.com
… Panel B is zoomed in on this subtree and its sister clade; at this scale, we can read individual
sample names and observe that this specific strain has been actively spreading in the …

[HTML][HTML] Stability of SARS-CoV-2 phylogenies

Y Turakhia, N De Maio, B Thornlow, L Gozashti… - PLoS …, 2020 - journals.plos.org
… When multiple branches in T’ match the branch b in T with the same best split distance, we
report all best-matching branches (Methods). Additionally, we confirmed that our statistic is a …

Transposable elements drive intron gain in diverse eukaryotes

L Gozashti, SW Roy, B Thornlow… - Proceedings of the …, 2022 - National Acad Sciences
… (B) Introners in Symbiodinium microadriaticum show clear evidence of 4 bp TSDs (shown
in green) and TIRs (underlined), consistent with many known DNA transposons, carry their 3′ …

[HTML][HTML] Pandemic-scale phylogenomics reveals elevated recombination rates in the SARS-CoV-2 spike region

Y Turkahia, B Thornlow, A Hinrichs, J McBroome… - BioRxiv, 2021 - biorxiv.org
… Specifically, we discover that the root of B.1.355 lineage might have resulted from a
recombination event between nodes belonging to the B.1.595 and B.1.371 lineages (Fig 3, Table S3)…

Transfer RNA genes experience exceptionally elevated mutation rates

BP Thornlow, J Hough, JM Roger… - Proceedings of the …, 2018 - National Acad Sciences
Transfer RNAs (tRNAs) are a central component for the biological synthesis of proteins, and
they are among the most highly conserved and frequently transcribed genes in all living …

Eukaryotic tRNA sequences present conserved and amino acid-specific structural signatures

E Westhof, B Thornlow, PP Chan… - Nucleic Acids …, 2022 - academic.oup.com
… The long-established nucleotide conservations, or semi-conservations, imposed on tRNA
sequences appear primarily in the loops and the portions of the A- and B-boxes in the D- and T…

matOptimize: a parallel tree optimization method enables online phylogenetics for SARS-CoV-2

C Ye, B Thornlow, A Hinrichs, A Kramer… - …, 2022 - academic.oup.com
… (B) An example of how matOptimize estimates the parsimony score improvement achievable
from a single SPR move using a small number of steps without redoing the entire Fitch …

Estimating the timing of multiple admixture pulses during local ancestry inference

P Medina, B Thornlow, R Nielsen, R Corbett-Detig - Genetics, 2018 - academic.oup.com
… Below, wherever possible, we give the script name and line number responsible for a
computation, denoted as h e a d e r : l i n e _ n u m b e r . All code is in the s r c / directory within the …