[HTML][HTML] Ultrafast Sample placement on Existing tRees (UShER) enables real-time phylogenetics for the SARS-CoV-2 pandemic
… b, UShER evaluations of the parsimony score for placing the sample S5 (blue) at each
possible position (Methods) of our example phylogeny (shown in a). We considered the branch …
possible position (Methods) of our example phylogeny (shown in a). We considered the branch …
[HTML][HTML] Pandemic-scale phylogenomics reveals the SARS-CoV-2 recombination landscape
… Specifically, we discover that the root of the B.1.355 lineage might have resulted from a
recombination event between nodes belonging to the B.1.595 and B.1.371 lineages (Fig. 3 and …
recombination event between nodes belonging to the B.1.595 and B.1.371 lineages (Fig. 3 and …
A daily-updated database and tools for comprehensive SARS-CoV-2 mutation-annotated trees
J McBroome, B Thornlow, AS Hinrichs… - Molecular biology …, 2021 - academic.oup.com
… Panel B is zoomed in on this subtree and its sister clade; at this scale, we can read individual
sample names and observe that this specific strain has been actively spreading in the …
sample names and observe that this specific strain has been actively spreading in the …
[HTML][HTML] Stability of SARS-CoV-2 phylogenies
… When multiple branches in T’ match the branch b in T with the same best split distance, we
report all best-matching branches (Methods). Additionally, we confirmed that our statistic is a …
report all best-matching branches (Methods). Additionally, we confirmed that our statistic is a …
Transposable elements drive intron gain in diverse eukaryotes
L Gozashti, SW Roy, B Thornlow… - Proceedings of the …, 2022 - National Acad Sciences
… (B) Introners in Symbiodinium microadriaticum show clear evidence of 4 bp TSDs (shown
in green) and TIRs (underlined), consistent with many known DNA transposons, carry their 3′ …
in green) and TIRs (underlined), consistent with many known DNA transposons, carry their 3′ …
[HTML][HTML] Pandemic-scale phylogenomics reveals elevated recombination rates in the SARS-CoV-2 spike region
… Specifically, we discover that the root of B.1.355 lineage might have resulted from a
recombination event between nodes belonging to the B.1.595 and B.1.371 lineages (Fig 3, Table S3)…
recombination event between nodes belonging to the B.1.595 and B.1.371 lineages (Fig 3, Table S3)…
Transfer RNA genes experience exceptionally elevated mutation rates
Transfer RNAs (tRNAs) are a central component for the biological synthesis of proteins, and
they are among the most highly conserved and frequently transcribed genes in all living …
they are among the most highly conserved and frequently transcribed genes in all living …
Eukaryotic tRNA sequences present conserved and amino acid-specific structural signatures
… The long-established nucleotide conservations, or semi-conservations, imposed on tRNA
sequences appear primarily in the loops and the portions of the A- and B-boxes in the D- and T…
sequences appear primarily in the loops and the portions of the A- and B-boxes in the D- and T…
matOptimize: a parallel tree optimization method enables online phylogenetics for SARS-CoV-2
C Ye, B Thornlow, A Hinrichs, A Kramer… - …, 2022 - academic.oup.com
… (B) An example of how matOptimize estimates the parsimony score improvement achievable
from a single SPR move using a small number of steps without redoing the entire Fitch …
from a single SPR move using a small number of steps without redoing the entire Fitch …
Estimating the timing of multiple admixture pulses during local ancestry inference
… Below, wherever possible, we give the script name and line number responsible for a
computation, denoted as h e a d e r : l i n e _ n u m b e r . All code is in the s r c / directory within the …
computation, denoted as h e a d e r : l i n e _ n u m b e r . All code is in the s r c / directory within the …