The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and
as such, offers a very powerful target for regulation of nociceptive transmission by both local …

Translational control through the mammalian target of rapamycin (mTOR) is critical for
synaptic plasticity, cell growth, and axon guidance. Recently, it was also shown that mTOR …

Pontospinal noradrenergic neurons are thought to form part of a descending endogenous
analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic …

Recent studies have demonstrated the importance of local protein synthesis for neuronal
plasticity. In particular, local mRNA translation through the mammalian target of rapamycin (…

Key points At the heart of the brain circuitry underlying fear behaviour is the periaqueductal
grey (PAG). We address an important gap in understanding regarding the neural pathways …

The management of neuropathic pain is unsatisfactory, and new treatments are required.
Because the sensitivity of a subset of fast-conducting primary afferent nociceptors is thought to …

Pontospinal noradrenergic neurons form part of an endogenous analgesic system that
suppresses acute pain, but there is conflicting evidence about its role in neuropathic pain. We …

The dorsal and ventral periaqueductal gray (dPAG and vPAG, respectively) are embedded
in distinct survival networks that coordinate, respectively, innate and conditioned fear-evoked …

The pivotal role of the periaqueductal grey (PAG) in fear learning is reinforced by the
identification of neurons in male rat ventrolateral PAG (vlPAG) that encode fear memory through …

The periaqueductal gray (PAG) coordinates behaviors essential to survival, including striking
changes in movement and posture (eg, escape behaviors in response to noxious stimuli vs …