Chemotherapeutic drugs used in the treatment of acute myeloid leukemias (AMLs) are thought
to induce cancer cell death through the generation of DNA double-strand breaks. Here, …

Differentiation therapies using all-trans retinoic acid (ATRA) are highly efficient at treating
acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML). However, …

Resistance to chemotherapeutic drugs is a major cause of treatment failure in acute myeloid
leukemias (AML). To better characterize the mechanisms of chemoresistance, we first …

TFF3 regulates essential gastro- and neuroprotective functions, but its molecular mode of
action remains poorly understood. Synthetic intractability and lack of reliable bioassays and …

MLK4 is a member of the mixed-lineage family of kinases that regulate the JNK, p38, and
ERK kinase signaling pathways. MLK4 mutations have been identified in various human …

Due to the essential roles of glutamate, detection and response to a large range of extracellular
concentrations of this excitatory amino acid are necessary for the fine-tuning of brain …

TFF1 is a key peptide for gastrointestinal protection and repair. Its molecular mechanism of
action remains poorly understood with synthetic intractability a recognised bottleneck. Here …

Extracellular vesicles (EVs) are nanosized lipid bilayer-encapsulated particles secreted by
virtually all cell types. EVs play an essential role in cellular crosstalk in health and disease. …

The effect of storage temperature on recrystallization and glass transition temperature (T g )
of nonwaxy and waxy rice starch gel systems containing 60% moisture content was …

The term cancer immunoediting describes the dual role by which the immune system can
both suppress and promote tumour growth and is divided into three phases: elimination, …