Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation
upon long-term (∼18–36 months) storage of two monoclonal antibody (mAb, mAb-A, …

The effects of a number of experimental parameters on the efficiency of ion transport by viscous
gas flow through narrow capillaries have been studied. Both electrospray and corona ion …

Signaling pathways intersecting with the p21-activated kinases (PAKs) play important roles
in tumorigenesis and cancer progression. By recognizing that the limitations of FRAX1036 (1…

Antibody–drug conjugates (ADCs) have emerged as valuable targeted anticancer
therapeutics with at least 11 approved therapies and over 80 advancing through clinical trials. …

De novo guanine biosynthesis is an evolutionarily conserved pathway that creates sufficient
nucleotides to support DNA replication, transcription, and translation. Bacteria can also …

Small molecule distribution coefficients between immiscible nonaqueuous and aqueous
phases—such as cyclohexane and water—measure the degree to which small molecules …

Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays
a central role in energy homeostasis and has been proposed as a therapeutic target in …

Polysorbates can undergo oxidative degradation in pharmaceutical formulations resulting in
both soluble and insoluble degradation products. The insoluble degradants may precipitate …

Modern small molecule drug design requires the optimization of not only the binding
characteristics of the molecule but also its physicochemical properties for ADMET performance. A …

Taking advantage of the C 2 -symmetry of the antitumor naturally occurring disorazole B 1
molecule, a symmetrical total synthesis was devised with a monomeric advanced intermediate …