Although deep learning has revolutionized protein structure prediction, almost all experimentally
characterized de novo protein designs have been generated using physically based …

P-glycoprotein (Pgp or multidrug-resistance protein) shows drug-stimulated ATPase activity.
The catalytic sites are known to be of low affinity and specificity for nucleotides. From the …

In nature, structural specificity in DNA and proteins is encoded differently: In DNA, specificity
arises from modular hydrogen bonds in the core of the double helix, whereas in proteins, …

The regular arrangements of β-strands around a central axis in β-barrels and of α-helices in
coiled coils contrast with the irregular tertiary structures of most globular proteins, and have …

Nucleic acids from bacteria or viruses induce potent immune responses in infected cells 1 ,
2 , 3 – 4 . The detection of pathogen-derived nucleic acids is a central strategy by which the …

The technique of vanadate trapping of nucleotide was used to study catalytic sites of P-glycoprotein
(Pgp) in plasma membranes from multidrug-resistant Chinese hamster ovary cells. …

The recent outbreak of Zika virus (ZIKV) has infected over 1 million people in over 30 countries.
ZIKV replicates its RNA genome using virally encoded replication proteins. Nonstructural …

Susceptibility to norovirus (NoV), a major pathogen of epidemic gastroenteritis, is associated
with histo-blood group antigens (HBGAs), which are also cell attachment factors for this …

The COVID‐19 pathogen, SARS‐CoV‐2, requires its main protease (SC2M Pro ) to digest
two of its translated long polypeptides to form a number of mature proteins that are essential …

Self-assembling cyclic protein homo-oligomers play important roles in biology, and the ability
to generate custom homo-oligomeric structures could enable new approaches to probe …