User profiles for Baptiste Libé-Philippot

Baptiste Libé-Philippot

KU Leuven - VIB
Verified email at kuleuven.be
Cited by 221

[PDF][PDF] Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits

…, R Iwata, A Ramaswamy, B Libé-Philippot… - Neuron, 2019 - cell.com
How neural circuits develop in the human brain has remained almost impossible to study at
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …

Cellular and molecular mechanisms linking human cortical development and evolution

B Libé-Philippot, P Vanderhaeghen - Annual review of genetics, 2021 - annualreviews.org
The cerebral cortex is at the core of brain functions that are thought to be particularly
developed in the human species. Human cortex specificities stem from divergent features of …

Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction

B Libé-Philippot, V Michel… - Proceedings of the …, 2017 - National Acad Sciences
Many genetic forms of congenital deafness affect the sound reception antenna of cochlear
sensory cells, the hair bundle. The resulting sensory deprivation jeopardizes auditory cortex (…

[PDF][PDF] LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons

B Libé-Philippot, A Lejeune, K Wierda, N Louros… - Cell, 2023 - cell.com
The enhanced cognitive abilities characterizing the human species result from specialized
features of neurons and circuits. Here, we report that the hominid-specific gene LRRC37B …

Human synaptic neoteny requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

B Libé-Philippot, R Iwata, AJ Recupero, K Wierda… - bioRxiv, 2023 - biorxiv.org
Human-specific (HS) genes are potential drivers of brain evolution, but their impact on human
neuron development and disease remains unclear. Here we studied HS genes SRGAP2B/…

LRRC37B is a species-specific regulator of voltage-gated channels and excitability in human cortical neurons

B Libé-Philippot, A Lejeune, K Wierda, I Vlaeminck… - bioRxiv, 2022 - biorxiv.org
The enhanced cognitive abilities characterizing the human species result from specialized
features of neurons and circuits, but the underlying molecular mechanisms remain largely …

Etude du rôle de protéines apparentées aux cadhérines dans le développement des interneurones du cortex auditif

B Libé-Philippot - 2017 - theses.hal.science
L'éminence ganglionnaire médiale (MGE) produit la grande majorité des interneurones
GABAergiques corticaux synthétisant la parvalbumine. Les neuroblastes issus de la MGE …

[HTML][HTML] INAUGURAL ARTICLE by a Recently Elected Academy Member: Auditory cortex interneuron development requires cadherins operating hair-cell …

B Libé-Philippot, V Michel, JB de Monvel… - Proceedings of the …, 2017 - ncbi.nlm.nih.gov
Many genetic forms of congenital deafness affect the sound reception antenna of cochlear
sensory cells, the hair bundle. The resulting sensory deprivation jeopardizes auditory cortex (…

Preprints bring 'firehose'of outbreak data

K Kupferschmidt - 2020 - science.org
Baptiste Libé-Philippot

Tempus fugit: How time flies during development

R Iwata, P Vanderhaeghen - Science, 2020 - science.org
“Fugit irreparabile tempus,” wrote Virgil, a reminder that our lives are defined by the irreversible
flow of time. As soon as the egg is fertilized, embryonic cells follow a developmental …