Pancreatic β-cells store insulin in secretory granules that undergo exocytosis upon glucose
stimulation. Sustained stimulation depletes β-cells of their granule pool, which must be …

Resealing after wounding, the process of repair following plasma membrane damage,
requires exocytosis. Vacuolins are molecules that induce rapid formation of large, swollen …

Electrophysiological studies in some secretory and non-secretory cells have identified an
extensive form of calcium-induced exocytosis that is rapid (hundreds of milliseconds), …

The human-specific gene ARHGAP11B is preferentially expressed in neural progenitors of
fetal human neocortex and increases abundance and proliferation of basal progenitors (BPs), …

Secretory granules of neuroendocrine cells store and release peptide hormones and
neuropeptides in response to various stimuli. Generation of granules from the Golgi complex …

Despite repeated exposure to HIV-1, certain individuals remain persistently uninfected. Such
exposed uninfected (EU) people show evidence of HIV-1–specific T cell immunity and, in …

Microtubules, polymers of the heterodimeric protein αβ-tubulin, give shape to cells and are
the tracks for vesicle transport and chromosome segregation. In vitro assays to study …

Background Baculovirus-mediated expression in insect cells is a powerful approach for
protein production. However, many existing methods are time-consuming, offer limited options …

We used yeast "two-hybrid" screening to isolate cDNA-encoding proteins interacting with the
N-terminal domain of the Ras nucleotide exchange factor CDC25 Mm . Three independent …

Detecting associations between genomic changes and phenotypic differences is fundamental
to understanding how phenotypes evolved. By systematically screening for parallel amino …