In vertebrates, skeletal muscle is a model for the acquisition of cell fate from stem cells 1 . Two
determination factors of the basic helix–loop–helix myogenic regulatory factor (MRF) family…

The growth and repair of skeletal muscle after birth depends on satellite cells that are
characterized by the expression of Pax7. We show that Pax3, the paralogue of Pax7, is also …

Satellite cells are adult skeletal muscle stem cells that are quiescent and constitute a poorly
defined heterogeneous population. Using transgenic Tg:Pax7-nGFP mice, we show that …

The myogenic determination genes Myf5, Myod and Mrf4 direct skeletal muscle cell fate
prenatally. In adult myogenesis, Myod has been shown to regulate myoblast differentiation, …

… Our previous studies showed that the elimination of 80-90% of the satellite cell population
still results in robust myofibre regeneration after 3-4 weeks (Gayraud-Morel et al., 2007), …

Skeletal muscle serves as a paradigm for the acquisition of cell fate, yet the relationship
between primitive cell populations and emerging myoblasts has remained elusive. We identify a …

Satellite cells assure postnatal skeletal muscle growth and repair. Despite extensive studies,
their stem cell character remains largely undefined. Using pulse-chase labelling with BrdU …

Background A longstanding goal in regenerative medicine is to reconstitute functional tissus
or organs after injury or disease. Attention has focused on the identification and relative …

During embryonic development, skeletal muscles arise from somites, which derive from the
presomitic mesoderm (PSM). Using PSM development as a guide, we establish conditions …

Genetic regulatory networks governing skeletal myogenesis in the body are well understood,
yet their hierarchical relationships in the head remain unresolved. We show that either …