Cell signaling that culminates in posttranslational modifications directs protein activity. Here
we report how multiple Ca 2+ -dependent phosphorylation sites within the transcription …

ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors. These
proteins direct gene expression in diverse normal and disease states by binding to specific …

Publisher Summary The discovery of ets proteins as transcription factors provided a framework
for understanding the oncogenic potential of ets genes. Ets proteins became a model …

The proto-oncogene ets-1 is the founding member of a new family of eukaryotic transcriptional
regulators. Using deletion mutants of murine ets-1 cDNA expressed in Escherichia coli, …

The conservation of in vitro DNA-binding properties within families of transcription factors
presents a challenge for achieving in vivo specificity. To uncover the mechanisms regulating …

The ETS gene family is frequently involved in chromosome translocations that cause human
cancer, including prostate cancer, leukemia, and sarcoma. However, the mechanisms by …

RNA polymerase (Pol) III transcribes many noncoding RNAs (for example, transfer RNAs)
important for translational capacity and other functions. We localized Pol III, alternative TFIIIB …

Sequence-specific DNA binding proteins that function as transcription factors are frequently
encoded by gene families. Such proteins display highly conserved DNA binding properties, …

▪ Abstract Autoinhibitory domains are regions of proteins that negatively regulate the function
of other domains via intramolecular interactions. Autoinhibition is a potent regulatory …

We have partially purified, from rat liver, a nuclear protein fraction with sequence-specific
affinity to a promoter domain shared by the herpesvirus tk gene and the Moloney murine …