The maintenance of cellular identity requires continuous adaptation to environmental
changes. This process is particularly critical for stem cells, which need to preserve their …

High attrition rates and loss of capital plague the drug discovery process. This is particularly
evident for mitochondrial disease that typically involves neurological manifestations and is …

Reprogramming somatic cells to a pluripotent state drastically reconfigures the cellular anabolic
requirements, thus potentially inducing cancer-like metabolic transformation. Accordingly…

Mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases. Modeling of
these defects has been difficult because of the challenges associated with engineering …

Leigh syndrome (LS) is a severe manifestation of mitochondrial disease in children and is
currently incurable. The lack of effective models hampers our understanding of the …

Huntington's disease ( HD ) is a neurodegenerative disorder caused by an expanded CAG
trinucleotide repeat in the huntingtin gene ( HTT ). Molecular chaperones have been …

The goal of our work has been to investigate the mechanisms of gender-independent human
skin ageing and examine the hypothesis of skin being an adequate model of global ageing…

RNAi is widely applied to inhibit expression of specific genes, but it is limited by variable
efficiency and specificity of empirically designed siRNA or shRNA constructs. This complicates …

The metabolic switch associated with the reprogramming of somatic cells to pluripotency
has received increasing attention in recent years. However, the impact of mitochondrial and …

Microarray analyses were performed to identify target genes that are shared by the acute
myeloid leukemia (AML) translocation products PML-RARα, PLZF-RARα and AML1-ETO in …