Interaction of background Ca2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca2+ waves in sheep heart

DC Hutchings, GWP Madders, BC Niort… - The Journal of …, 2022 - Wiley Online Library
Ventricular arrhythmias can cause death in heart failure (HF). A trigger is the occurrence of
Ca 2+ waves which activate a Na + ‐Ca 2+ exchange (NCX) current, leading to delayed after‐…

Serial block face scanning electron microscopy reveals region-dependent remodelling of transverse tubules post-myocardial infarction

T Perera, C Pius, B Niort… - … of the Royal …, 2022 - royalsocietypublishing.org
The highly organized transverse tubule (t-tubule) network facilitates cardiac excitation–contraction
coupling and synchronous cardiac myocyte contraction. In cardiac failure secondary …

[HTML][HTML] Cardiomyocyte-specific loss of plasma membrane calcium ATPase 1 impacts cardiac rhythm and is associated with ventricular repolarisation dysfunction

C Wilson, N Stafford, M Zi, A Chelu, BC Niort… - Journal of molecular and …, 2022 - Elsevier
Plasma membrane calcium ATPase 1 (PMCA1, Atp2b1) is emerging as a key contributor to
cardiac physiology, involved in calcium handling and myocardial signalling. In addition, …

[HTML][HTML] Critical Link between Calcium Regional Heterogeneity and Atrial Fibrillation Susceptibility in Sheep Left Atria

BC Niort, A Recalde, C Cros, F Brette - Journal of Clinical Medicine, 2023 - mdpi.com
Background: Atrial fibrillation is the most sustained form of arrhythmia in the human
population that leads to important electrophysiological and structural cardiac remodeling as it …

A novel minimally invasive and reproducible large animal ischaemia-reperfusion-infarction model: methodology and model validation

C Pius, B Niort, EJ Radcliffe, AW Trafford - bioRxiv, 2023 - biorxiv.org
Ischaemic heart disease remains a leading cause of premature mortality and morbidity.
Understanding the associated pathophysiological mechanisms of cardiac dysfunction arising …

BS9 Regional alterations to the transverse-tubule network in an ovine model of myocardial infarction

T Perera, C Pinali, E Radcliffe, B Niort, C Pius… - 2021 - heart.bmj.com
The highly organised transverse tubule (t-tubule) network consisting of invaginations of the
cell sarcolemma facilitates synchronous cardiac myocyte contraction. This study aimed to …

Impaired β-adrenergic responsiveness of failing ventricular myocytes from an ovine myocardial infarction-induced heart failure model

B Niort, C Pius, D Eisner, K Dibb, A Trafford - Journal of Molecular and …, 2022 - Elsevier
Methods MI was induced in sheep by inflating an angioplasty balloon after the second
diagonal of the left anterior descending artery for 90 min. Cardiac function was then monitored …

Transverse-tubule remodelling in remote and border regions following myocardial infarction

…, C Pinali, E Radcliffe, B Niort… - Microscience …, 2021 - research.manchester.ac.uk
Serial block face scanning electron microscopy (SBF-SEM) was used to image ventricular
cardiac myocytes in healthy and myocardial infarction (MI) sheep. 3-dimensional renderings of …

[PDF][PDF] La REF

S Barbara - 2005 - ffe.com
… Lancées sur la dernière boucle du Championnat du Monde d'endurance, Barbara
Record battu aussi pour la vente de la jument restée aux émirats : Barbara retrace son rêve …

[CITATION][C] Proteoglycans modulation of cardiac extracellular matrix elastic properties in health and myocardial infarction

…, C Pius, E Radcliffe, B Niort… - 89th Harden …, 2023 - research.manchester.ac.uk
… Cristal Collado Rojas, Peter Stanley, Charlene Pius, Emma Radcliffe, Barbara Niort,
Luigi Venetucci, Katharine Dibb, Andrew Trafford, Christian Pinali …