While the catalog of mammalian transcripts and their expression levels in different cell types
and disease states is rapidly expanding, our understanding of transcript function lags behind…

The Polycomb group (PcG) protein Eed is implicated in regulation of imprinted X-chromosome
inactivation in extraembryonic cells but not of random X inactivation in embryonic cells. …

Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed
the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) …

Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific
gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-…

Mapping genetic interactions (GIs) by simultaneously perturbing pairs of genes is a powerful
tool for understanding complex biological phenomena. Here we describe an experimental …

▪ Abstract Dosage compensation in mammals is achieved by the transcriptional inactivation
of one X chromosome in female cells. From the time X chromosome inactivation was initially …

In many multicellular organisms, males have one X chromosome and females have two.
Dosage compensation refers to a regulatory mechanism that insures the equalization of X-…

Dosage compensation requires the fine tuning of transcription of X-linked genes in response
to mechanisms that detect a 2-fold difference in X chromosome number. Though unique …

The X-linked Xist gene encodes a large untranslated RNA that has been implicated in
mammalian dosage compensation and in spermatogenesis. To investigate the function of the Xist …

Histone lysine residues can be mono-, di-, or trimethylated. These posttranslational
modifications regulate the affinity of effector proteins and may also impact chromatin structure …