Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons
counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be …

Each protein must be synthesized with the correct amino acid sequence, folded into its native
structure, and transported to a relevant subcellular location and protein complex. If any of …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two
neurodegenerative diseases in which similar pathogenic mechanisms are involved. Both diseases …

The cellular response to cancer-induced stress is one of the major aspects regulating cancer
development and progression. The Heat Shock Protein B8 (HSPB8) is a small chaperone …

Amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA) are two
motoneuron diseases (MNDs) characterized by aberrant protein behavior in affected cells. …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that primarily affects
motoneurons, while non-neuronal cells may contribute to disease onset and progression. …

Valosin containing protein (VCP) has emerged as a central protein in the regulation of the
protein quality control (PQC) system. VCP mutations are causative of multisystem …

Three missense mutations targeting the same proline 209 (Pro209) codon in the co-chaperone
Bcl2-associated athanogene 3 (BAG3) have been reported to cause distal myopathy, …

Transforming growth factor beta (TGFB) is a pleiotropic cytokine known to be dysregulated
in many neurodegenerative disorders and particularly in amyotrophic lateral sclerosis (ALS). …

Chaperone-assisted selective autophagy (CASA) is a highly selective pathway for the
disposal of misfolding and aggregating proteins. In muscle, CASA assures muscle integrity by …