▪ Abstract Animal models have been invaluable for studying aspects of food intake regulation
that for various reasons cannot be observed in humans. The dairy cow is a unique animal …

To determine whether inflammation can induce bovine fatty liver, we administered recombinant
bovine tumor necrosis factor-α (rbTNF) to late-lactation Holstein cows. Cows (n = 5/…

Mammalian females pay high energetic costs for reproduction, the greatest of which is imposed
by lactation. The synthesis of milk requires, in part, the mobilization of bodily reserves to …

Human untargeted metabolomics studies annotate only ~10% of molecular features. We
introduce reference-data-driven analysis to match metabolomics tandem mass spectrometry (…

Adapting to the lactating state requires metabolic adjustments in multiple tissues, especially
in the dairy cow, which must meet glucose demands that can exceed 5 kg/day in the face of …

Inflammation may be a major contributing factor to peripartum metabolic disorders in dairy
cattle. We tested whether administering an inflammatory cytokine, recombinant bovine tumor …

The reported effects of feeding on growth hormone (GH) secretion in ruminants have been
inconsistent, and are likely influenced by energy status of animals. High-producing dairy cows …

The study of adipose tissue (AT) is enjoying a renaissance. White, brown, and beige
adipocytes are being investigated in adult animals, and the critical roles of small depots like …

Dietary choline can impact systemic immunity, but it remains unclear whether this is primarily
via direct impacts on immune cells or secondary effects of altered metabolic function. To …

Negative energy balance (NEB) is associated with metabolic disorders in early lactation dairy
cows. Therefore, our objective was to characterize the liver proteome in cows experiencing …