One of the most pervasive challenges in molecular phylogenetics is the incongruence
between phylogenies obtained using different data sets, such as individual genes. To …

The serious shortage of human organs available for transplantation has engendered a
heightened interest in the use of animal organs (xenografts) for transplantation. However, the …

Similar phenotypic changes have evolved independently in many animal taxa. It is unknown
whether independent changes involve the same or different developmental and genetic …

Some species of parasites occur on a wide range of hosts while others are restricted to one
or a few host species. The host specificity of a parasite species is determined, in part, by its …

The production of genetically engineered pigs as xenotransplant donors aims to solve the
severe shortage of organs for transplantation in humans. The first barrier to successful …

… Barry Williams completed this work as a doctoral student at the University of Illinois. He is
currently a postdoctoral researcher at the University of Wisconsin and is interested in the …

Bacteria can evolve rapidly under positive selection owing to their vast numbers, allowing
their genes to diversify by adapting to different environments. We asked whether the same …

Hyperacute rejection (HAR) is the first critical immunological hurdle that must be addressed
in order to develop xenogeneic organs for human transplantation. In the area of cell‐based …

Intracellular triacylglycerol (TAG) is a ubiquitous energy storage lipid also involved in lipid
homeostasis and signaling. Comparatively, little is known about TAG’s role in other cellular …

Hsp70 molecular chaperones are ubiquitous. By preventing aggregation, promoting folding,
and regulating degradation, Hsp70s are major factors in the ability of cells to maintain …