User profiles for Bart O. Williams
 | Bart O. WilliamsVan Andel Research Institute Verified email at vai.org Cited by 23116 |
Tumor spectrum analysis in p53-mutant mice
T Jacks, L Remington, BO Williams, EM Schmitt… - Current biology, 1994 - cell.com
Background: The p53 tumor suppressor gene is mutated in a large percentage of human
malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit one …
malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit one …
[HTML][HTML] TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
Mutation in the TSC2 tumor suppressor causes tuberous sclerosis complex, a disease
characterized by hamartoma formation in multiple tissues. TSC2 inhibits cell growth by acting as a …
characterized by hamartoma formation in multiple tissues. TSC2 inhibits cell growth by acting as a …
Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis
MD Castellone, H Teramoto, BO Williams, KM Druey… - Science, 2005 - science.org
How cyclooxygenase-2 (COX-2) and its proinflammatory metabolite prostaglandin E2 (PGE2)
enhance colon cancer progression remains poorly understood. We show that PGE2 …
enhance colon cancer progression remains poorly understood. We show that PGE2 …
[HTML][HTML] Essential role of β-catenin in postnatal bone acquisition
…, L Deng, TL Clemens, BO Williams - Journal of Biological …, 2005 - ASBMB
Mutations in the Wnt co-receptor LRP5 alter bone mass in humans, but the mechanisms
responsible for Wnts actions in bone are unclear. To investigate the role of the classical Wnt …
responsible for Wnts actions in bone are unclear. To investigate the role of the classical Wnt …
SR proteins and splicing control 1569
…, AK Hopper, CN Cole, MH Lee, BO Williams… - Genes …, 1996 - genesdev.cshlp.org
DEVELOFMEIST Page 1 VOLUME 10 GENES (Eh DEVELOFMEIST NUMBER 13 PAGES
1569-1710 July 1, 1996 EDITORIAL BOARD J. Adams (Melbourne, Australia) J. Beckwith (Boston …
1569-1710 July 1, 1996 EDITORIAL BOARD J. Adams (Melbourne, Australia) J. Beckwith (Boston …
A subset of p53-deficient embryos exhibit exencephaly
Defects in neural tube formation are among the most common malformations leading to infant
mortality. Although numerous genetic loci appear to contribute to the defects observed in …
mortality. Although numerous genetic loci appear to contribute to the defects observed in …
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
THE retinoblastoma tumour-suppressor gene (RB) has been implicated in negative growth
regulation, induction of differentiation, and inhibition of cellular transformation 1 . …
regulation, induction of differentiation, and inhibition of cellular transformation 1 . …
Lrp5 functions in bone to regulate bone mass
…, H Gerrits, JA Gossen, X He, M Bader, BO Williams… - Nature medicine, 2011 - nature.com
The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein
5 (LRP5). To understand how LRP5 influences bone properties, we generated mice with …
5 (LRP5). To understand how LRP5 influences bone properties, we generated mice with …
Cooperative tumorigenic effects of germline mutations in Rb and p53
BO Williams, L Remington, DM Albert, S Mukai… - Nature …, 1994 - nature.com
The tumour suppressor genes Rb and p53 are mutated in several types of human cancer,
and many tumour types carry mutations in both genes. To study how these genes normally …
and many tumour types carry mutations in both genes. To study how these genes normally …
[PDF][PDF] mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
Epidermal integrity is a complex process established during embryogenesis and maintained
throughout the organism lifespan by epithelial stem cells. Although Wnt regulates normal …
throughout the organism lifespan by epithelial stem cells. Although Wnt regulates normal …